Electron microscopic observations of muscle dedifferentiation in regenerating Amblystoma limbs☆
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Cited by (140)
Spinal cord regeneration — the origins of progenitor cells for functional rebuilding
2022, Current Opinion in Genetics and DevelopmentCitation Excerpt :Dedifferentiation has long been associated with regenerative repair, describing a mature cell that reverts into a progenitor/stem cell, giving rise to cells of its own lineage or potentially other cell lineages (Figure 2). A classic example of dedifferentiation was first inferred from static images of a regenerating salamander limb, indicating that mature nucleated muscle fibers were pinching off single nuclei to form cells that would populate the injury site through a process of dedifferentiation [30]. It has been widely postulated for decades that many animals that can regenerate utilize dedifferentiation to form a mass of undifferentiated stem cells adjacent to the injury site termed a blastema, which will eventually differentiate to replace lost structures.
The Axolotl's journey to the modern molecular era
2022, Current Topics in Developmental BiologyCitation Excerpt :Beautiful TEM work from Elizabeth Hay suggested that terminally dedifferentiated muscle fibers in the salamander limb in fact dedifferentiated in response to limb amputation. From high quality serial images of the regenerating limb blastema she inferred that the muscle fibers pinched off of single cells, which then entered the blastema (Hay, 1959). The idea that terminally differentiated cells would dedifferentiate was a highly controversial idea.
Salamanders: The molecular basis of tissue regeneration and its relevance to human disease
2021, Current Topics in Developmental Biology
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Supported by grant C-3708 from the National Institutes of Health, United States Public Health Service.