Full paperIdentification of a secondary sperm receptor in the mouse egg zona pellucida: Role in maintenance of binding of acrosome-reacted sperm to eggs
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Fertilization
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Species-specific mechanisms during fertilization
2020, Current Topics in Developmental BiologyCitation Excerpt :The human ZP consists of four such proteins, ZP1–4, while in mice, there are only three, ZP1–3 (Gupta et al., 2012). Even though ZP3 does play a role in sperm-zona binding (Bleil, Greve, & Wassarman, 1988; Bleil & Wassarman, 1980, 1983; Miller, Macek, & Shur, 1992), another ZP component, ZP2, was shown to be the primary sperm-binding factor (Rankin et al., 1998) (Fig. 1A). ZP2 exhibits taxon specificity, such that mouse sperm can bind mouse eggs transgenically expressing mouse or human ZP2, whereas human sperm exhibits greater selectivity and binds only to eggs expressing human ZP2 (Baibakov, Boggs, Yauger, Baibakov, & Dean, 2012).
Assisted Reproduction
2019, Yen & Jaffe's Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management: Eighth EditionStructure of Zona Pellucida Module Proteins
2018, Current Topics in Developmental BiologyEgg Coat Proteins Across Metazoan Evolution
2018, Current Topics in Developmental BiologyCitation Excerpt :In mice, it was found that solubilized ZP3 inhibited sperm binding to ovulated mouse eggs in vitro, whereas solubilized ZP1 and ZP2 did not, suggesting that in mice the egg coat receptor for sperm is ZP3 (Bleil & Wassarman, 1980). ZP3 is able to trigger the acrosome reaction, and acrosome-reacted sperm bind to ZP2, making ZP3 the primary receptor for sperm and ZP2 the secondary receptor (Arnoult, Zeng, & Florman, 1996; Bleil, Greve, & Wassarman, 1988; Bleil & Wassarman, 1983, 1986; Jungnickel, Sutton, Wang, & Florman, 2007; Wassarman & Litscher, 2016). Over time, it was shown that O-glycans on serine-332 and -334 in the C-terminus of ZP3, located in a so-called sperm combining site, are essential for gamete recognition, and that their postfertilization cleavage could account for another observation in mice: the inability of mouse sperm to bind to solubilized ZPs from two-cell embryos (Baibakov et al., 2012; Chen, Litscher, & Wassarman, 1998; Florman & Wassarman, 1985).
Egg-Coat and Zona Pellucida Proteins of Chicken as a Typical Species of Aves
2018, Current Topics in Developmental BiologyThe Mouse Egg's Zona Pellucida
2018, Current Topics in Developmental BiologyCitation Excerpt :Results of experiments in the 1970s strongly suggested that solubilized ZP preparations from unfertilized hamster and mouse eggs contained sperm receptors (Gwatkin, 1977). This suggestion was extended in the 1980s and 1990s by evidence demonstrating that AI sperm bind to ZP3 and AR sperm bind to ZP2 of ovulated eggs (Bleil & Wassarman, 1980c, 1983, 1986; Bleil, Greve, & Wassarman, 1988; Mortillo & Wassarman, 1991; Vazquez et al., 1989) (Fig. 7). This led to the conclusion that both ZP3 and ZP2 are receptors for sperm and that ZP3 induces the ARx (Wassarman, 1987, 1988b, 1999).
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