Haloperidol-induced disruption of conditioned avoidance responding: Attenuation by prior training or by anticholinergic drugs
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Dopamine signals related to appetitive and aversive events in paradigms that manipulate reward and avoidability
2019, Brain ResearchCitation Excerpt :Tonic DA levels, measured by microdialysis probes, tend to be higher in the striatum during both the acquisition and maintenance of avoidance behavior (McCullough et al., 1993; Dombrowski et al., 2013). Interestingly, DA does not appear to be necessary for escape behaviors; broadly inhibiting DA using the antipsychotic haloperidol or other DA antagonists prevent animals from acquiring avoidance behavior, while leaving escape behaviors intact (Fibiger et al., 1975; Arnt, 1982; Wadenberg et al., 1990). It is likely that the effectiveness of antipsychotics in disrupting avoidance stems from their ability to block D2-type receptors, whose activation is thought to promote active defense behaviors (Beninger et al., 1980; Beninger, 1983, 1989; Kapur, 2003; Smith et al., 2005; Lloyd and Dayan, 2016).
Immunohistochemical evidence for the involvement of gonadotropin releasing hormone in neuroleptic and cataleptic effects of haloperidol in mice
2016, NeuropeptidesCitation Excerpt :Therefore, the present immunohistochemical study was carried out to find out the presence of GnRH after HAL treatment to vehicle/GnRH antagonist pre-treated mice. The ability of HAL to suppress CAR and induce catalepsy is well demonstrated in mouse and rats (Fibiger et al., 1975; Britton et al., 1992; Kobayashi et al., 1997; Khisti et al., 1997). However, the ability of GnRH antagonist to block these effects of HAL is reported only in rats (Umathe et al., 2009).
Long-term consequences of early experience on adult avoidance learning in female rats: Role of the dopaminergic system
2007, Neurobiology of Learning and MemoryFrom dopamine to salience to psychosis-linking biology, pharmacology and phenomenology of psychosis
2005, Schizophrenia Research