Endothelial phagocytosis: An electron-microscopic study

doi:10.1016/0014-4800(65)90034-1

Experimental and Molecular Pathology

Volume 4, Issue 2, April 1965, Pages 217-231

https://doi.org/10.1016/0014-4800(65)90034-1 Get rights and content

Abstract

The RES of rats and mice was “overloaded” by repeated injections of colloidal carbon, and the non-RES vascular endothelium was examined by electron microscopy for evidence of phagocytosis. Phagocytosis of carbon was demonstrated in the endothelium of small myocardial vessels, in the endocardium, in pulmonary capillary endothelium, in the aorta, and in glomerular and peritubular capillary endothelium. Some carbon remained in the endothelium of the heart vessels for at least 7 days after overloading. Carbon particles were also present in circulating mononuclear cells and in perivascular phagocytes.

This study thus confirms—at the level of the electron microscope—the ability of vascular endothelium outside the RES to perform phagocytosis.

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^☆: This work was supported by grants from the U.S. Public Health Service (HE 0825-01, HE 06275, and 2G-113).

View full text

Endothelial phagocytosis: An electron-microscopic study☆

Abstract

J. Ultrastruct. Res.

Endothelium: Its Development, Morphology, Function and Pathology

Localization of colloidal substances in vascular endothelium. A mechanism of tissue damage. 1. Factors causing the pathologic deposition of colloidal carbon

Am. J. Pathol.

The fine structure of endothelium of large arteries

J. Biophys. Biochem. Cytol.

Effects of varying the vehicle for OsO4 in tissue fixation

J. Biophys. Biochem. Cytol.

Studies on the localization of circulating antigen-antibody complexes and other macromolecules in vessels: 1. Structural studies

J. Exptl. Med.

Essai de localization infrastructurelle dans le poumon des elements du system reticulo endotheliel

Compt. Rend. Soc. Biol.

Glomerular permeability. 1. Ferritin transfer across the normal glomerular capillary

J. Exptl. Med.

Comparative observations on the fine structure of blood capillaries

Studies on Pagocytic Stimulation

An electron microscopic study of the hepatic uptake and excretion of submicroscopic particles injected into the blood stream and bile duct

Acta Anat.

India ink and reticuloendothelial blockade

Arch. Pathol.

Stoffanreicherung in Retikuloendothel und in der Niere

The transport of particles across the walls of small blood vessels

Simple methods for “staining with lead” at high pH in electron microscopy

J. Biophys. Biochem. Cytol.

The metabolic basis of phagocytic activity

Phys. Rev.

Effects of varying the vehicle for OsO₄ in tissue fixation