Synthesis of tetrahydrobiopterin in friend erythroleukemia cells and its modulator effect on cell proliferation☆
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2010, American Journal of PathologyCitation Excerpt :Yet we observed that antiangiogenesis targeting GTPCH expression and BH4 synthesis had not affected tumor stromal fibroblast cell proliferation or growth. This does not agree with several previous reports, where exogenously added BH4 promoted the proliferation of hemopoietic cells, mouse erythroleukemia and rat C6 glioma cells.45–47 That could reflect unexpected side effects of high doses of Sep (100 μmol/L) or nonspecific growth factor stimulation.
Effect of antisense oligodeoxynucleotide for sepiapterin reductase on the viability of PC12 cells in the presence of exogenous carbonyl compounds
2003, Chemico-Biological InteractionsCitation Excerpt :Besides functioning as a specific enzyme for the formation of BH4 (Fig. 1), SPR in PC12 cells may serve for detoxification of exogenous carbonyl compounds via its so-called carbonyl reductase activity. Some previous reports indicated that exogenous BH4 stimulated DNA synthesis and cell proliferation [10,11]. We also observed in this study, that the cell number significantly decreased by the transfection with Anti-Oligo even when the cells were not treated with phenylpropanedione.
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This work was supported by the Deutsche Forschungsgemeinschaft, the Bundesministerium für Forschung und Technologie and the Thyssen-Stiftung.