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Cited by (59)
A deletion in Eml1 leads to bilateral subcortical heterotopia in the tish rat
2020, Neurobiology of DiseaseCitation Excerpt :Recently, Taylor et al. (2019) showed that these rhythms were present in wild-caught Brown-Norway rats. This finding, combined with previous demonstrations of retained awareness during these bursts (Drinkenburg et al., 2003; Wiest and Nicolelis, 2003), has resulted in increasing recognition that these rhythms may not be pathogenic (Kaplan, 1985; Taylor et al., 2019). Independent of whether these bursts in the rat are pathogenic or not, an improved understanding of the macro- and micro-circuits that generate pathogenic and normal brain rhythms remains valuable to understanding the functioning of neural networks (Ryan and Sharpless, 1979; Halgren et al., 2019).
Impact of strain, sex, and estrous cycle on gamma butyrolactone-evoked absence seizures in rats
2018, Epilepsy ResearchCitation Excerpt :Finally, Wistar rats have likewise been reported to display spontaneous SWDs with a penetrance of ∼40%; as with Sprague-Dawley rats, these discharges were more common in females as compared to males (80% vs 34%, respectively) (Vergnes et al., 1982). While the functional significance of these SWDs remains a topic of debate (Ewell, 2017; Kaplan, 1985; Rodgers et al., 2015; Taylor et al., 2018; Wiest and Nicolelis, 2003), the greater sensitivity to GBL in Long Evans animals is seemingly consistent with a predisposition to initiate spontaneous thalamocortical oscillations in this strain. Anecdotally, we have regularly observed spontaneous SWDs in Long Evans rats obtained from Charles River; and less frequently in Wistar and Sprague-Dawley rats obtained from Harlan/Envigo.
The relevance of inter- and intrastrain differences in mice and rats and their implications for models of seizures and epilepsy
2017, Epilepsy and BehaviorCitation Excerpt :Extensive analysis in Wistar rats has shown that 5–9 Hz oscillations alone generally do not lead to seizure activity; however, epileptic SWD activity may emerge following induced or natural genetic alterations, such as in the GAERS (Genetic Absence Epilepsy Rat from Strasbourg) Wistar rat [137]. As observed in mouse strains, several outbred and inbred rat strains exhibit bilaterally symmetrical SWDs (8–11 Hz; sometimes also termed high-voltage rhythmic spike [HVRS] discharges, high-voltage cortical oscillations, or electrocortical polyspiking [139–142]) in the cortical EEG. These EEG alterations are associated with sudden arrest of ongoing behavior (immobility) involving occasional facial/whisker twitching, and can be suppressed by ethosuximide, thus behaving as absence-like seizure activity [143–146].
Strain Effects on Expression of Seizures and Epilepsy
2017, Models of Seizures and Epilepsy: Second Edition
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This work was supported by grant A7898 from the National Sciences and Engineering Research Council of Canada. I thank B. Gillis, L. Austin, S. Ligertwood, and J. Fraser for technical assistance, and T. Allison for critical comments.