Disturbed myelinogenesis and recovery in hyperphenylalaninemia in rats: An immunohistochemical study
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Morphometric analysis of gray matter integrity in individuals with early-treated phenylketonuria
2016, Molecular Genetics and MetabolismCitation Excerpt :However, converging evidence from animal and human research suggest that cortical gray matter is also affected in PKU. Studies employing murine models of PKU have found reduced GM thickness [19], nerve cell size [20], synaptic density [21,22], and dendritic arborization [23] in PKU mice/rats compared to wild-type animals. In addition, early histological studies of humans with untreated PKU reported GM effects including stunted dendritic growth [24], decreased dendritic spines [25], reduced nerve cell size [24], and less distinct cortical lamination [24] compared healthy individuals without PKU.
ADHD, learning, and academic performance in phenylketonuria
2010, Molecular Genetics and MetabolismClinical analysis of West syndrome associated with phenylketonuria
2001, Brain and DevelopmentMagnetic resonance imaging in phenylketonuria: Reversal of cerebral white matter change
1995, The Journal of PediatricsMagnetic resonance imaging of the brain in phenylketonuria
1994, The Lancet
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