Gastroenterology

Gastroenterology

Volume 109, Issue 6, December 1995, Pages 1917-1925
Gastroenterology

Effect of volume expansion on systemic hemodynamics and central and arterial blood volume in cirrhosis

https://doi.org/10.1016/0016-5085(95)90759-9Get rights and content

Abstract

Background & Aims: Systemic vasodilatation in cirrhosis may lead to hemodynamic alterations with reduced effective blood volume and decreased arterial blood pressure. This study investigates the response of acute volume expansion on hemodynamics and regional blood volumes in patients with cirrhosis and in controls. Methods: Thirty-nine patients with cirrhosis (12 patients with Child-Turcotte class A, 14 with class B, and 13 with class C) and 6 controls were studied. During hepatic vein catheterization, cardiac output, systemic vascular resistance, central and arterial blood volume, noncentral blood volume, and arterial pressure were determined before and during a volume expansion induced by infusion of a hyperosmotic galactose solution. Results: During volume expansion, the central and arterial blood volume increased significantly in patients with class A and controls, whereas no significant change was found in patients with either class B or class C. Conversely, the noncentral blood volume increased in patients with class B and C. In both patients and controls, the cardiac output increased and the systemic vascular resistance decreased, whereas the mean arterial blood pressure did not change significantly. Conclusions: Only in mild cirrhosis is the effective blood volume able to increase in response to volume expansion. Our results are consistent with the peripheral vasodilatation hypothesis and the circulatory hyporeactivity occurring in advanced cirrhosis.

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    Supported by The John and Birthe Meyer Foundation and The Danish Hospital Foundation for Medical Research, Region of Copenhagen, The Faroe Islands, and Greenland. Søren Møller holds a research fellowship at the University of Copenhagen, Copenhagen, Denmark.

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