Scrapie in mice: Some effects on the brain lesion profile of ME7 agent due to genotype of donor, route of injection and genotype of recipient

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Abstract

ME7 scrapie agent which had been passaged in either BALBc or BRVR mice was injected by either the intracerebral or intraperitoneal route into mice from these 2 inbred strains: inocula were prepared from either brain or spleen. In terms of the intensity of grey matter vacuolation in 9 areas of the brain, jointly considered as a profile of lesion distribution, it was found that route of injection had the largest effect on the degree of vacuolation and that the effect of route depended significantly on the particular combinations of genotypes of donor and recipient which were used.

The genotypes of donor and recipient had highly significant effects on the shape of the lesion profile, but these effects were of smaller magnitude than that due to route. The finding that genotype of donor affected the lesion profile even for the i.p. route of injection is discussed in terms of various models for pathogenesis and agent replication.

References (14)

  • A.G. Dickinson et al.

    J. comp. Path.

    (1968)
  • A.G. Dickinson et al.

    J. comp. Path.

    (1973)
  • A.C. Gardiner

    Res. vet. Sci.

    (1966)
  • S.W. Greenhouse et al.

    Psychometrika

    (1959)
  • I.H. Pattison et al.

    Res. vet. Sci.

    (1967)
  • W. Arber
  • A.G. Dickinson
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