Mutant insulin crystal packing

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Abstract

A comparative study between mutant and native insulins in different crystal forms and structural conformations has revealed certain differences among these insulins in terms of crystal packing. In general, mutations involved in crystal contacts may cause change in the lattice organization. This change, however, may facilitate internal interactions in mutants. More work is needed before we are able to predict crystal growth by judging the effect of mutations on lattice contacts.

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