Journal of Molecular Biology

Journal of Molecular Biology

Volume 87, Issue 4, 25 August 1974, Pages 853-858
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Letter to the editor
Membrane proteins: Amino acid sequence and membrane penetration

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Abstract

A computer study shows that the membrane-penetrating portion of the erythrocyte surface MN-glycoprotein (Winzler, 1969; Marchesi et al., 1972) is distinguishable by informal cluster analysis from other segments of globular proteins when sequence length is plotted against hydrophobicity This analysis further suggests the possibility that other membrane-penetrating segments of proteins can be identified in the same way.

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