Journal of Molecular Biology
Letter to the editorEvidence for Drosophila P element transposase activity in mammalian cells and yeast☆
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Sleeping Beauty transposition: Biology and applications for molecular therapy
2004, Molecular TherapyCitation Excerpt :This is because the vast majority of DNA transposons in vertebrate genomes were inactivated millions of years ago [17], thereby prohibiting the isolation of an element convertible into a gene transfer vector. To circumvent this problem, the idea of adapting invertebrate transposons for use in vertebrates has been around for quite some time [18]. Indeed, some transposons show activity in species phylogenetically distant from their original host.
Sleeping beauty, a wide host-range transposon vector for genetic trensformation in vertebrates
2000, Journal of Molecular BiologyCitation Excerpt :However, a number of transposon systems require specific host proteins for transposition, which limits their mobility outside their natural hosts. For example, P elements are active only in drosophilid flies (Rio et al., 1988). A number of experiments from different laboratories have shown that Tc1/mariner elements can be adapted as potentially useful vectors for vertebrate genetics (for a review, see Plasterk et al., 1999 and see references therein).
Resident aliens the Tc1/mariner superfamily of transposable elements
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This work was supported by grant GM33135 from the National Institutes of Health. D.C.R. is a Lucille P. Markey Scholar and this work was supported in part by a grant from the Lucille P. markey Charitable Trust.
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Present address: Whitehead Institute, Nine Cambridge Center, Cambridge, MA 02142, U.S.A.