Increased estrogen-16α-hydroxylase activity in women with breast and endometrial cancer

doi:10.1016/0022-4731(84)90021-9

Journal of Steroid Biochemistry

Volume 20, Issue 4, Part 2, April 1984, Pages 1077-1081

https://doi.org/10.1016/0022-4731(84)90021-9 Get rights and content

Abstract

We have measured the three principal oxidative transformations of estradiol by means of a radiometric procedure in women with breast or endometrial cancer and in age matched controls. No difference between the 17β-o1 oxidation or 2-hydroxylation of the hormone was observed between the study groups. In contrast, 16α-hydroxylation was strikingly elevated in the women with breast and endometrial cancer relative to the age matched controls. Evidence is presented that this increased activity precedes the clinical evidence of the disease and that it represents a significant risk factor for these estrogen dependent tumors. This risk may be mediated by one of the products of 16α-hydroxylation, 16α-hydroxyestrone, which exhibits unique biological properties.

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IV. Estril and cancerIncreased estrogen-16α-hydroxylase activity in women with breast and endometrial cancer

Abstract

Eur. J. Cancer

Lancet

J. biol. Chem.

Hormone profiles in hormone dependent cancers

Cancer Res.

Estrogen profiles of premenopausal women with breast cancer

Cancer Res.

An overview of hormone-associated cancers

Cancer Res.

Reduced estriol excretion in patients with breast cancer prior to endocrine therapy

JAMA

Etiology of human breast cancer: a review

J. natn Cancer Inst.

A review of the epidemiology of human breast cancer

Epidem. Rev.

Direction of estradiol metabolism as a control of its hormonal action —uterotropic activity of estradiol metabolites

Endocrinology

Nuclear binding and retention of the receptor estrogen complex: relation to the agonistic and antagonistic properties of estriol

Endocrinology

Biological properties of 16α-hydroxyestrone: implications in estrogen physiology and pathophysiology

J. clin. Endocr. Metab.

IV. Estril and cancer
Increased estrogen-16α-hydroxylase activity in women with breast and endometrial cancer