Elsevier

Life Sciences

Volume 28, Issue 24, 15 June 1981, Pages 2727-2736
Life Sciences

Taurine mobilizing effects of beta alanine and other inhibitors of taurine transport

https://doi.org/10.1016/0024-3205(81)90173-9Get rights and content

Abstract

Oral administration of a 3% beta alanine solution in the drinking water was as effective in increasing urinary taurine excretion and decreasing tissue taurine levels in rats as subcutaneous or intraperitoneal administration. Beta alanine was more effective in reducing tissue taurine levels in rats and guinea pigs than in mice. Other inhibitors of taurine transport were compared with beta alanine for their ability to reduce tissue taurine levels. Taurocyamine, the guanidino analogue of taurine, was less effective in rats than beta alanine in reducing taurine levels in gastrocnemius but more effective in reducing brain taurine levels, whereas the homologue of beta alanine, GABA, was relatively ineffective in either mice or rats.

References (28)

  • J.B. Gilbert et al.

    J. Biol. Chem.

    (1960)
  • R. Huxtable et al.

    J. Nutr.

    (1972)
  • D.G. Spaeth et al.

    J. Nutr.

    (1974)
  • J.A. Sturman et al.

    J. Nutr.

    (1978)
  • J.A. Sturman

    J. Nutr.

    (1973)
  • J. Graff et al.

    J. Biol. Chem.

    (1950)
  • A. Pihl et al.

    J. Biol. Chem.

    (1955)
  • H. Iwata et al.

    Japan J. Pharmacol.

    (1979)
  • J.G. Jacobsen et al.

    Physiol. Rev.

    (1968)
  • J.J. Kocsis et al.
  • H. Goldman et al.

    Pediatr. Res.

    (1967)
  • Z.N. Gaut et al.
  • D.S. Grosso et al.

    J. Clin. Invest.

    (1978)
  • J.J. Kocsis et al.

    The Pharmacologist

    (1963)
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    Present address: Dept. of Pharmacology, University of Tennessee Center for the Health Sciences, Memphis, TN 38163

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