Elsevier

Life Sciences

Volume 51, Issue 18, 1992, Pages 1419-1426
Life Sciences

Both cyclooxygenase and lipoxygenase inhibitor partially restore the anorexia by interleukin-1β

https://doi.org/10.1016/0024-3205(92)90536-XGet rights and content

Abstract

Since the peripheral prostaglandin synthetizing system may at least partly involved in the anorexia that follows central interleukin-1β (IL-1) administration, this study was undertaken to investigate the effect of ibuprofen (ip), selective cyclooxygenase blocker and AA 861, selective lipoxygenase inhibitor, on changes of food and water intake by a single injection of IL-1 (2 μg/rat, ip). We demonstrated that food and water intake were suppressed by peripheral administration of IL-1. Throughout the entire observation periods, suppressed food intake was partially restored to control levels by ibuprofen, while water intake completely restored. In addition, no significant differences about water/food intake were observed in the IL-1 + ibuprofentreated groups, respectively. In the next experiment, IL-1 induced anorexia was also partially restored to the control level following pretreatment with AA 861. These results may suggest that other mechanism including lipoxygenase blocker besides prostaglandin production may be involved in IL-1 induced anorexia.

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    IL-1β has an increasingly recognized role in the regulation of feeding behavior and energy homeostasis. IL-1β potently suppresses food intake when injected peripherally and centrally [140,141] and unlike IL-1β-mediated fever, the anorexic effect of IL-1β is not completely blocked by inhibition of PG synthesis [142,143]. Further, administration of IL-1ra into the lateral ventricle abrogates sickness behavior induced by peripheral IL-1β without affecting the febrile response [141].

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