Ouabain and low extracellular potassium inhibit PTH secretion from bovine parathyroid cells by a mechanism that does not involve increases in the cytosolic calcium concentration
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The electrophysiological development of cardiomyocytes
2016, Advanced Drug Delivery ReviewsCitation Excerpt :Regardless, the important role played by IKr in phase 3 of repolarization is illustrated by the increased susceptibility to arrhythmias when the function of these channels is impaired or reduced [32]. It should be mentioned that the contributions of IKr to phase 3 repolarization are reinforced by IK1 which also has biophysical properties that cause the outward K+ movement to increase as the membrane potential hyperpolarizes towards the phase 4 RP; these features are linked to unblock of the channels from block by endogenous Mg2 + and polyamines [33]. The progressive (i.e. regenerative) increases in IK1 and IKr with phase 3 repolarization ultimately overcomes the inherent tendency of increased Ca2 + entry through L-type Ca2 + channels thereby ensuring a return to the RP.
The secretory response of parathyroid hormone to acute hypocalcemia in vivo is independent of parathyroid glandular sodium/potassium-ATPase activity
2011, Kidney InternationalCitation Excerpt :This impedes the possibilities for studying parathyroid cell function. Previous studies describing an effect of ouabain on PTH secretion were all performed in in vitro models of dispersed bovine parathyroid cells or mouse thyroparathyroids.12–14,20 It is well known that parathyroid cells loose their phenotype very fast in in vitro systems.21–24
Regulation of hormone secretion and cytosolic Ca<sup>2+</sup> by extracellular Ca<sup>2+</sup> in parathyroid cells and C-cells: Role of voltage-sensitive Ca<sup>2+</sup> channels
1988, Archives of Biochemistry and BiophysicsFurosemide stimulation of parathormone in humans: role of the calcium-sensing receptor and the renin-angiotensin system
2015, Pflugers Archiv European Journal of PhysiologyAdvances in understanding the role of cardiac glycosides in control of sodium transport in renal tubules
2014, Journal of Endocrinology