Islet somatostatin-microvascular, paracrine, and pulsatile regulation
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Cited by (55)
Characterization of somatostatin receptors and associated signaling pathways in pancreas of R6/2 transgenic mice
2018, Biochimica et Biophysica Acta - Molecular Basis of DiseaseCitation Excerpt :The perturbed function of hormone producing cells in the islets of Langerhans is regulated by several members of the GPCR family amongst them somatostatin receptor (SSTRs) play a pivotal role [12–16]. SST, a growth hormone inhibiting peptide, has shown to be affected in the central nervous system (CNS) as well as in peripheral tissues including the pancreas of R6/2 mice [17–19]. The role of SST in the regulation of insulin and glucagon secretion and release in the pancreas is well established, the act if perturbed, is associated with the progression of diabetes [20,21].
Paracrine and autocrine interactions in the human islet: More than meets the eye
2013, Seminars in Cell and Developmental BiologyCitation Excerpt :This implies that the direction of blood flow does not dictate whether a particular paracrine interaction is possible or not in human islets, as has been suggested [20]. For instance, somatostatin has been disregarded as a paracrine signal because delta cells in mouse islets were assumed to be located downstream of beta cells and thus would not be able influence beta cells through the vascular route [20,21]. Given the cytoarchitecture of the human islet, paracrine interactions can occur via interstitial spaces and do not require vascular perfusion.
Chapter 21 Pancreatic Network Control of Glucagon Secretion and Counterregulation
2009, Methods in EnzymologyCitation Excerpt :Some of the well-documented relationships between different islet cell signals are summarized in the following subsections. Pancreatic perfusions with antibodies to insulin, somatostatin, and glucagon have suggested that the blood within the islets flows from β- to α- to δ-cells in dogs, rats, and humans (Samols and Stagner, 1988, 1990; Stagner et al., 1988, 1989). It was then proposed that, insulin regulates glucagon, which in turn regulates somatostatin.
Function and expression of somatostatin receptors of the endocrine pancreas
2008, Molecular and Cellular EndocrinologyGhrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis
2008, Pharmacology and Therapeutics