Elsevier

Metabolism

Volume 40, Issue 2, February 1991, Pages 214-216
Metabolism

Tissue-specific regulation of lipoprotein lipase activity by insulin/glucose in normal-weight humans

https://doi.org/10.1016/0026-0495(91)90178-YGet rights and content

Abstract

Eight normal-weight subjects (four men, four women) were studied to determine the relative activities of lipoprotein lipase (LPL) in adipose tissue (ATLPL) and vastus lateralis skeletal muscle (SMLPL), both in the fasting state and in response to a 6-hour insulin/glucose infusion. Mean fasting levels of ATLPL and SMLPL were not statistically different. After 6 hours of insulin/glucose infusion, mean ATLPL activity was significantly greater than the fasting level (P < .01), while mean SMLPL activity decreased from basal (P < .05). These tissue-specific changes in LPL responsiveness (0 to 6 hours) were significantly different (P < .01). No differences between men and women were observed. These divergent tissue-specific LPL responses to insulin/glucose would serve to direct lipoprotein triglyceride-derived fatty acids away from muscle and to adipose tissue for storage.

References (18)

There are more references available in the full text version of this article.

Cited by (0)

Supported by National Institutes of Health Grant No. DK-26356 and a grant (RR-0005) from the GCRC with computations assistance from CLINFO funded under the GCRC grant.

View full text