The effects of iron deficiency on brain biogenic monoamine biochemistry and function in rats
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The roles of iron and HFE genotype in neurological diseases
2020, Molecular Aspects of MedicineCitation Excerpt :Iron deficient microglia fail to respond to LPS stimulus and have decreased IL-1β expression (Rosato-Siri et al., 2018) and IL-1β has been previously shown to promote remyelination through the induction of IGF-1 (Mason et al., 2001) further tying the link between iron and myelination (Connor and Kettenmann, 2013). Beyond cell division, neurons need adequate and timely iron supply for dendritic arborization, synapse formation, and neurotransmitter synthesis (Youdim et al., 1980; Rudisill et al., 2019; Bastian et al., 2016). For example, tyrosine hydroxylase and tryptophan hydroxylase involved in synthesis of monoamines (dopamine and serotonin) use iron as a cofactor.
Iron and mechanisms of emotional behavior
2014, Journal of Nutritional BiochemistryCitation Excerpt :A large body of evidence has indicated that impaired emotional behaviors are associated with iron deficiency through altered dopamine metabolism [14,20,74,75]. In general, there is a universal negative effect of iron deficiency on dopamine functions [11,76,77], which are specific to brain region and the stage of neural development. Dopamine receptor 1 (D1R) expression is down-regulated in the caudate putamen and prefrontal cortex of iron-deficient rats [78].
Waterborne manganese exposure alters plasma, brain, and liver metabolites accompanied by changes in stereotypic behaviors
2012, Neurotoxicology and TeratologyCitation Excerpt :Changes in these exploratory behaviors contradict typical nocturnal behavior (Scheer et al., 2003) and suggest that Mn-exposure may disrupt the circadian clock. Sleep disturbances are common among Parkinson's disease patients (Suzuki et al., 2011), and reversal of the circadian rhythm has been observed in iron deficient rats and is attributed to alterations in dopaminergic and/or noradrenergic activity (Youdim et al., 1980). In addition to dopamine and norepinephrine, circadian rhythm is largely influenced by serotonin, GABA, and glutamate in the suprachiasmatic nucleus (Wagner et al., 2001; Reghunandanan and Reghunandanan, 2006), and circadian fluctuations in dopamine, glutamate, and GABA have been reported in the striatum of rats (Castaneda et al., 2004).
Delayed alternation performance in rats following recovery from early iron deficiency
2010, Physiology and BehaviorCitation Excerpt :That is, the current protocol induced a significant level of ID (upwards of 40% brain iron loss) [4,9,12]. Thus, other dietary protocols that used different amounts of iron deficient ciao [1,2,14,15,19–21] may have resulted in a different pattern of behavioral findings. Finally, the findings of Lozoff and colleagues [27] showing long-term deficits in executive functions in adolescents who had been iron deficient as young children were collected in a population that experienced longer-term postnatal ID.
Effects of prolonged iron overload and low frequency electromagnetic exposure on spatial learning and memory in the young rat
2009, Neurobiology of Learning and MemoryConsumption of caprine milk improves metabolism of calcium and phosphorus in rats with nutritional ferropenic anaemia
2007, International Dairy Journal
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Present address: Israel Institute of Technology—Technion, School of Medicine, Department of Pharmacology, 12 Haaliya Street, Bat-Galim, POB 9649, Haifa. Israel.