Chemosensitivity of rat nasal trigeminal receptors
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Cited by (81)
Olfactory stimulation Inhibits Nociceptive Signal Processing at the Input Stage of the Central Trigeminal System
2021, NeuroscienceCitation Excerpt :On the stimulation day, mice were kept in the laboratory in their IVC home cage for 1 hour before starting the experiments. Allyl isothiocyanate (AITC, Sigma-Aldrich, Munich, Germany, #377430; vapor pressure at 20 °C: 5.21 hPa) was chosen as an established trigeminal stimulus in rodents (Anton et al., 1991; Bereiter, 1997; Takeda et al., 1999; Ro et al., 2003), whereas phenethyl alcohol (PEA, Sigma-Aldrich, Munich, Germany, #W285811; vapor pressure at 20 °C: 0.08 hPa) was used as pure olfactory stimulus that does not induce activity in the trigeminal ethmoid nerve of rats, even at saturating concentrations (Silver and Moulton, 1982). The second odorant tested was lavender oil (Sigma-Aldrich, Munich, Germany, #61718), diluted to 1:10.000 with Milli-Q water.
3.20 - Oral Chemesthesis and Taste
2020, The Senses: A Comprehensive Reference: Volume 1-7, Second EditionSensory irritation of vapours of formic, acetic, propionic and butyric acid
2018, Regulatory Toxicology and PharmacologyCitation Excerpt :In rats, 50-min exposure to acetic acid caused an increase in nasal vasodilation, at least partly, due to activation of the nasal sensory nerves (Stanek et al., 2001). Also in rats, 10 s inhalation-exposure to vapours of propionic acid activated the trigeminal nerves (Silver and Moulton, 1982). Furthermore, flushing the rat nose with formic, acetic and propionic acid caused activation of the trigeminal nerves in a concentration-dependent manner (Wang et al., 2011).
Peripheral modulation of smell: Fact or fiction?
2013, Seminars in Cell and Developmental BiologyCitation Excerpt :The more medial branch of the ophthalmic nerve, called the ethmoid nerve, innervates olfactory epithelium and olfactory bulb, alike [41] (Fig. 2). Although trigeminal innervation of the olfactory epithelium is considered to be sensory [42–45], these fibers contain and may release substance P (Fig. 3E and F), CGRP [40], and ATP through axonal reflex. Surprisingly, little work has been done to examine neuropeptide/neurotransmitter release by trigeminal fibers within the olfactory epithelium, although in vivo and in vitro studies have shown that trigeminal ganglia can release ATP and substance P [46].
Topographical differences in distribution and responsiveness of trigeminal sensitivity within the human nasal mucosa
2010, PainCitation Excerpt :Whereas C-fibers are involved in the mediation of burning pain sensation [47,54,33], Aδ-fibers mediate sharp, stinging sensation [54,33]. A number of studies (e.g., [10,11,46,34]) have established that intranasal trigeminal fibers act as a detection system for noxious chemicals and trigger protective respiratory reflexes [48]. Free nerve endings of trigeminal fibers in the nasal mucosa are not covered by squamous epithelium, which provides most chemicals nearly free access to receptors [21] that innervate the nasal mucosa, increasing the sensitivity to painful stimuli [16].
Oral Chemesthesis and Taste
2008, The Senses: A Comprehensive Reference