AriticleUse of running wheels regulates the effects of the ovaries on circadian rhythms
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Cited by (24)
Sex differences in daily timekeeping and circadian clock circuits
2022, Seminars in Cell and Developmental BiologyCitation Excerpt :Most rodent species display changes in circadian period when gonadal hormones are manipulated in adulthood. Ovariectomy can increase period length in hamsters and rats [151,171], although this effect may depend on the presence of a running wheel [137]. After ovariectomy, estradiol replacement shortens free-running period by 10–20 min in female hamsters, rats, and mice [5,112,136,149,171].
Ovariectomy influences the circadian rhythm of locomotor activity and the photic phase shifts in the volcano mouse
2017, Physiology and BehaviorCitation Excerpt :It is possible that, in Neotomodon, estrogens modulate the photic sensitivity to light in the early subjective that indirectly impacts the photic induction of PER1 and PER2. The influence of estrogens upon the circadian clockwork involves receptors ERα and ERβ, both present in the SCN of rodents [57,85–87], and in structures considered as inputs and outputs of the SCN [72,88]. Therefore, estrogens may act directly or indirectly on the circadian behavior.
Estradiol enhances light-induced expression of transcription factors in the SCN
2004, Brain ResearchCitation Excerpt :Interestingly, it has been suggested that behavioral activity may interact with photic information to regulate circadian rhythms and immediate early gene expression in the SCN of rodents [13,35,43]. Given that both endogenous and exogenous estradiol increase spontaneous locomotor activity as well as various measures of arousal in female rats [8,44,55], it is also possible that the estradiol-induced enhancement of the expression of transcription factors in the SCN is mediated through estrogen sensitive regions that underlie arousal-mediated phase shifts [30,50]. This proposition is particularly intriguing given that both the raphe and the preoptic area: (1) are estrogen sensitive [7,54]; (2) project to the SCN [12,29]; and (3) play a role in the mechanisms that regulate locomotor activity [17,36,58].
Estrogens and non-reproductive behaviors related to activity and fear
2004, Neuroscience and Biobehavioral ReviewsCitation Excerpt :Further, estrogens cannot be seen simply as ‘nature's psychoprotectant’ that they commonly are believed to be. The animal literature concerning the influence of estrogens on affect and activity levels points to estrogens as having generally stimulating effects on activity levels ([14–21]; for review, see Refs. [22–24]). However, as with humans, estrogenic effects in animals on emotional responses are varied, with elevations in estrogens producing a range of responses on tests of anxiety and fear [25–32] (and see below).
Estrogen's effects on activity, anxiety, and fear in two mouse strains
2002, Behavioural Brain ResearchEffects of estrogen on activity and fear-related behaviors in mice
2001, Hormones and Behavior
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Current address: Department of Oncology, University College and Middlesex School of Medicine, 91 Riding House Street, London W1P 8BT.