Quantification of exercise capability and evaluation of physical capacity in man

https://doi.org/10.1016/0033-0620(76)90008-6Get rights and content

Abstract

  • 1.

    (1) Every type of exercise is in a sense a unique situation. However, all forms of muscular work do increase the metabolic rate and therefore it is of particular interest to analyse the involvement of the oxygen transport system. The oxygen uptake gives an accurate measure of the aerobic power, and it is highly related to the cardiac output. The V̇O2 max is under standardized conditions a highly reproducible characteristic of the individual's aerobic fitness. It is, however, subject to variations under certain conditions (i.e., after prolonged inactivity, after training, as a consequence of cardiac diseases). The main factor behind such variations in V̇O2 max is proportional changes in the stroke volume. Therefore a recording of the heart rate during exercise at a given oxygen uptake will reflect these variations in longitudinal studies. Generally speaking, a high heart rate is usually associated with a low stroke volume. However, from this information it is not possible to tell whether this (poor) exercise response was caused by genetic factors, lack of training, impaired heart function, or other factors.

  • 2.

    (2) Data have been presented suggesting that the maximal transport of oxygen (cardiac output X oxygen content of arterial blood) is limited by the central circulation rather than by the tissues' ability to utilize the oxygen.

  • 3.

    (3) A multi-stage exercise test on a treadmill or bicycle ergometer will provide a measurement of the rate of work an individual is able to tolerate without symptoms or electro-cardiographic abnormalities.

  • 4.

    (4) For a prediction of the subject's ability to move his body the maximal oxygen uptake per kilogram body weight should be calculated. However, an evaluation of the cardiac performance should be based on the total oxygen transport (liter V̇O2/min), for that is correlated to the cardiac output, the myocardial oxygen consumption and blood flow. Variation in the body-fat content is not followed by similar changes in the dimensions of muscles, heart, blood volume etc., and demands for local blood flow. In other words, in a heterogenous group of individuals the V̇O2 X kg−1 X min−1 value is unrelated to the actual load on their hearts. One good measure of the cardiac performance is the ratio of oxygen uptake/heart rate.

  • 5.

    (5) There is not one test protocol ideal for all situations. It is recommended that one adapts the initial rate of work and the increment in work intensity to the assumed maximal power of the tested person. The work time on each stage should if possible be at least 3 min; the larger the increments in rate of work, the longer the work time on each stage. If the main purpose of the exercise test is to establish the V̇O2 max or symptom-limited work tolerance one can apply a nonsteady-state protocol with 1–2 min on each stage.

  • 6.

    (6) For the investigator who is willing to accept the small but definite risk involved, a multi-stage test carried to symptom-limited or maximal power will provide the clearest results, particularly for a differentiation between normals and coronary heart disease patients.

  • 7.

    (7) It is an alternative to terminate the multistage exercise test at a heart rate close to 195 minus the age (years) of the subject. For most individuals that means a submaximal test. The third alternative is to simulate on a bicycle ergometer or treadmill the metabolic rate of the subject's job and recreational activities.

Repeated single-stage or multi-stage tests give excellent measures of variations in physical conditioning (changes in body weight must be considered in a treadmill test).

References (40)

  • I Åstrand

    The physical work capacity of workers 50–64 years old

    Acta Physiol Scand

    (1958)
  • I Åstrand

    Aerobic work capacity in men and women with special reference to age

    Acta Physiol Scand

    (1960)
  • I Åstrand

    Blood pressure during physical work in a group of 221 women and men 48–63 years old

    Acta Med. Scand

    (1965)
  • I Åstrand

    The “minnesota code” for ECG classification. Adaptation to CR leads and modification of the code for ECG's recording during and after exercise

    Acta Med Scand

    (1967)
  • I Åstrand et al.

    Reduction in maximal oxygen uptake with age

    J Appl Physiol

    (1973)
  • P-O Åstrand et al.

    Textbook of Work Physiology

  • B Balke et al.

    An experimental study of physical fitness of air force personnel

    US Armed Forces Med J

    (1959)
  • RA Binkhorst et al.

    A rapid method for the determination of aerobic capacity

    Intern Z Angew Physiol

    (1963)
  • H Blackburn

    Measurement in Exercise Electrocardiography

    (1969)
  • RA Bruce

    Exercise testing of patients with coronary heart disease

    An Clin Res

    (1971)
  • CTM Davies et al.

    Physiological response to one- and two-leg exercise breathing air and 45% oxygen

    J Appl Physiol

    (1974)
  • B Ekblom et al.

    The influence of physical training and other factors on the subjective rating of perceived exertion

    Acta Physiol Scand

    (1971)
  • B Ekblom et al.

    Response to exercise after blood loss and reinfusion

    J Appl Physiol

    (1972)
  • B Ekblom et al.

    Effects of atropine and propranolol on the oxygen transport system during exercise in man

    Scand J Clin Lab Invest

    (1972)
  • B Ekblom et al.

    Effect of changes in arterial oxygen content on circulation and physical performance

    J Appl Physiol

    (1975)
  • L Fagraeus

    Cardiorespiratory and metabolic functions during exercise in hyberbaric environment

    Acta Physiol Scand

    (1974)
  • VF Froelicher et al.

    A comparison of three maximal treadmill exercise protocols

    J Appl Physiol

    (1974)
  • PD Gollnick et al.

    Enzyme activity and fiber composition in skeletal muscle of untrained and trained men

    J Appl Physiol

    (1972)
  • L Hermansen et al.

    Cardiac output during submaximal and maximal treadmill and bicycle exercise

    J Appl Physiol

    (1970)
  • L Hermansen et al.

    Oxygen uptake during maximal treadmill and bicycle exercise

    J Appl Physiol

    (1969)
  • Cited by (152)

    • An update in toxicology of ageing

      2021, Environmental Toxicology and Pharmacology
    • Individual variations in platelet reactivity towards ADP, epinephrine, collagen and nitric oxide, and the association to arterial function in young, healthy adults

      2019, Thrombosis Research
      Citation Excerpt :

      A submaximal exercise test was performed on a Monark bike (Monark Sports and Medical, Monark 939E, Vansbro, Sweden) with simultaneous ECG registration to monitor heart rate (Cardiolex, EC Sense, Solna, Sweden). The exercise test was performed to assess cardiorespiratory fitness by calculating maximal oxygen uptake (VO2) [15] as previously described [12]. Venous blood was collected from over-night fasting subjects, using a 21-gauge butterfly needle (Vacuette®, Greiner Bio-One International GmbH, Kremsmünster, Austria) and immediately when blood flow was established the tourniquet was released.

    • Fluctuation of the left ventricular ejection fraction in patients with HER2-positive early breast cancer treated by 12 months of adjuvant trastuzumab

      2018, Breast
      Citation Excerpt :

      In patients with cardiac dysfunction, slight decrease may impact the physical ability of patients to face prolonged physical exercises. Indeed, for many years, it has been thought that normal or near-normal exercise capacity is reflected by a normal left ventricular function [18–21]. To date, no study has shown the clinical impact of a small fluctuation of LVEF on extenuating activities, and also their effect on the quality of life of patients.

    View all citing articles on Scopus
    View full text