Elsevier

Steroids

Volume 59, Issue 4, April 1994, Pages 270-273
Steroids

Paper
The metabolism of estrone sulfate in the female rhesus monkey

https://doi.org/10.1016/0039-128X(94)90112-0Get rights and content

Abstract

In order to study the metabolism of estrone sulfate in the adult female rhesus monkey, we gave four monkeys a pulse injection of [3H]estrone sulfate and obtained blood samples at 15, 30, 60, 120, 300, and 1,440 minutes after the pulse. All blood samples were analyzed for [3H]estrone sulfate. The mean ±SE for the initial volume of distribution was 4.6 ± 0.9 L. The mean metabolic clearance rate (MCR) was 42.0 ± 2.9 L/day. In addition, 2 monkeys were infused for 240 minutes with [3H]estrone sulfate and 5 monkeys were infused for 240 minutes with [3H]estrone sulfate/[14C]estrone. Three blood samples were obtained during the last hour of the infusions and analyzed for radioactivity as estrone sulfate, estrone, and estradiol, and MCRs, conversion ratios, and [ϱ]BB values were calculated. The mean ± SE for the MCR was 67.5 ± 8.3 L/day, and for the conversion ratio, estradiol to estrone sulfate was 0.054 ± 0.016. The mean [ϱ]BB value for estrone sulfate conversion to estrone was 43.6 ± 3.4% and for estrone conversion to estrone sulfate was 33.5 ± 6.6%. Thus estrone sulfate is cleared slowly and is converted to both estrone and estradiol. The hydrolysis of estrone sulfate to estrone is not significantly different than conversion of estrone to estrone sulfate. (Steroids 59: 270–273, 1994)

References (16)

There are more references available in the full text version of this article.

Cited by (5)

  • Simulating kinetic parameters in transporter mediated permeability across Caco-2 cells. A case study of estrone-3-sulfate

    2011, European Journal of Pharmaceutical Sciences
    Citation Excerpt :

    Based on that, two more variables Ma and Mb are used to represent mannitol quantities at the apical and basolateral sides respectively. E1S may be metabolized inside the cell (Davis and Kelsey, 1950; Longcope et al., 1994). This is represented in the model by an exponential decay δL Lc.

View full text