Elsevier

Thermochimica Acta

Volume 250, Issue 2, 15 February 1995, Pages 305-318
Thermochimica Acta

Other paper
From whole body to molecule: an integrated approach to the regulation of metabolism and growth

Presented at the Ninth Conference of the International Society for Biological Calorimetry, Berlin-Schmerwitz, 27–31 May 1994, and dedicated to Ingolf Lamprecht on the occasion of his 60th birthday.
https://doi.org/10.1016/0040-6031(94)01967-LGet rights and content

Abstract

This paper considers the use of whole-body calorimetry in a wide context, as one of a range of techniques available for advancing our knowledge of the regulation of energy metabolism and growth. This integrated approach should lead to a greater depth of understanding by investigating the mechanisms by which responses of the whole animal depend on events at the tissue, cellular and molecular levels.

Two critical stages of mammalian development, the perinatal and early postnatal periods, are discussed. Particular attention is paid to skeletal muscle and the extent to which myofibre differentiation and hypertrophy, and hence muscle function and energetic efficiency, can be modified by nutrition and the thermal environment. In view of the crucial roles of thyroid hormones, growth hormone and insulin-like growth factor-I in regulation of metabolism and growth, the role of the endocrine system is also considered. These studies have important implications for survival and optimal health of humans and other animals.

References (68)

  • P. Herpin et al.

    Adaptive changes in oxidative metabolism in skeletal muscle of cold-acclimated piglets

    J. Therm. Biol.

    (1992)
  • M. Kleiber

    The Fire of Life: An Introduction to Animal Energetics

    (1975)
  • K. Blaxter

    Energy Metabolism in Animals and Man

    (1989)
  • J.A. McLean et al.

    Animal and Human Calorimetry

    (1987)
  • M. Ashwell

    McCance & Widdowson: A Scientific Partnership of 60 Years

    (1993)
  • A. Lucas

    Programming by early nutrition in man

  • D.J.P. Barker

    The effect of nutrition of the fetus and neonate on cardiovascular disease in adult life

    Br. J. Nutr.

    (1992)
  • M.J. Dauncey

    Activity and energy expenditure

    Can. J. Physiol. Pharmacol.

    (1990)
  • J.C. Waterlow

    Mechanisms of adaptation to low energy intakes

  • M.J. Dauncey

    Thyroid hormones and thermogenesis

  • V.K.K. Chatterjee et al.

    Thyroid hormone receptors and their role in development

  • M.J. Dauncey

    Nutrition and the thyroid

    Eur. J. Clin. Nutr.

    (1992)
  • J.-P. Thissen et al.

    Nutritional regulation of the insulin-like growth factors

    Endocr. Rev.

    (1994)
  • M.J. Dauncey

    Metabolic effects of altering the 24 h energy intake in man, using direct and indirect calorimetry

    Br. J. Nutr.

    (1980)
  • M.J. Dauncey

    Nutrition and development of the low birth-weight infant

  • D.L. Ingram et al.

    Man and Animals in Hot Environments

    (1975)
  • P. Herpin et al.

    Relation between plasma concentration of insulin-like growth factor-I and birth-weight in pigs

    J. Physiol. (Lond.)

    (1992)
  • M.J. Dauncey et al.

    Nutritional modulation of insulin-like growth factor-I expression in early postnatal piglets

    Pediatr. Res.

    (1994)
  • M. Hayashi et al.

    Heat production and respiratory enzymes in normal and runt newborn piglets

    Biol. Neonate

    (1987)
  • J.R. Hill et al.

    Oxygen consumption in normally grown, small-for-dates and large-for-dates newborn infants

    J. Physiol. (Lond.)

    (1968)
  • P. Chessex et al.

    Metabolic consequences of intrauterine growth retardation in very low birthweight infants

    Pediatr. Res.

    (1984)
  • M.J. Dauncey et al.

    Thyroid hormone nuclear receptors in skeletal muscle as influenced by environmental temperature and energy intake

    Q.J. Exp. Physiol.

    (1988)
  • R. Geers et al.

    Time course of the change in nuclear 3,5,3′-triiodothyronine receptors of skeletal muscle in relation to energy intake

    Q.J. Exp. Physiol.

    (1988)
  • K. Cotterell et al.

    Thermal and nutritional influences on cardiac muscle 3,5,3′-triiodothyronine nuclear receptors

    Horm. Metab. Res.

    (1991)
  • Cited by (0)

    View full text