The minimal oral toxicity level for mevinphos in man

doi:10.1016/0041-008X(75)90198-2

Toxicology and Applied Pharmacology

Volume 32, Issue 1, April 1975, Pages 97-100

https://doi.org/10.1016/0041-008X(75)90198-2 Get rights and content

Abstract

Four groups, of five human volunteers each, were fed various doses of mevinphos daily for 30-day periods to determine its effect on plasma and erythrocyte (RBC) cholinesterase with the following results: 1.0 mg had no effect, 1.5 and 2.0 mg each produced a 20% or greater decrease in RBC cholinesterase on one occasion only, while 2.5 mg produced a steady decrease in RBC cholinesterase reaching a maximum of 25% on the 27th day of administration. None of these doses affected the plasma cholinesterase activity. From these results we conclude that 2.5 mg mevinphos meets the criterion for minimal incipient toxicity, which is defined as the amount producing a decrease of 20–25% below control cholinesterase activity.

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The minimal oral toxicity level for mevinphos in man

Abstract

Toxicol. Appl. Pharmacol.

Toxicol. Appl. Pharmacol.