Elsevier

Toxicon

Volume 16, Issue 2, 1978, Pages 198-200
Toxicon

Short communication
Resistance of woodrats (Neotoma micropus) to Crotalus atrox venom

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Cited by (32)

  • The importance of species: Pygmy rattlesnake venom toxicity differs between native prey and related non-native species

    2018, Toxicon
    Citation Excerpt :

    For example, Mackessy et al. (2006) suggested that inbred house mice may have limited utility for comprehending the natural roles of venoms in snakes that consume primarily non-mammalian prey. Even within mammals, the house mouse may be a poor model as it has substantially lower resistance to venom compared to native mammals such as the woodrat (Neotoma micropus) and California ground squirrels (Otospermophilus beecheyi) as evidenced by traditional LD50 or serum-protective LD50 tests (Perez et al., 1978; Poran et al., 1987). Additionally, in invertebrates, captive bred desert locusts (Schistocerca gregaria) were poor proxies for assessing saw-scaled viper (Echis sp.) venom toxicity and performance on natural scorpion prey (Richards et al., 2012).

  • Coevolution takes the sting out of it: Evolutionary biology and mechanisms of toxin resistance in animals

    2017, Toxicon
    Citation Excerpt :

    One of these inhibitors appears to be a member of the immunoglobulin supergene family and shows similarity with inter-α trypsin inhibitor (Biardi et al., 2011), a factor previously known to interact with and modulate matrix metalloproteinases, to which the SVMPs are distantly related (Huxley-Jones et al., 2007; Casewell, 2012). Reports of other types of North American squirrels exhibiting degrees of resistance against rattlesnake venoms have implicated serum based resistance (Perez et al., 1978b; Pomento et al., 2016), providing an interesting model to investigate whether similar inhibitory components have evolved or been convergently upregulated in this mammalian family (Sciuridae). Interestingly, a number of other mammals possess serum-based enzyme inhibitors that offer varying degrees of protection from the toxins found in viperid snake venoms (see Pérez and Sánchez, 1999; Perales et al., 2005 for comprehensive reviews).

  • Functional basis of a molecular adaptation: Prey-specific toxic effects of venom from Sistrurus rattlesnakes

    2009, Toxicon
    Citation Excerpt :

    In particular, it would be of great interest to compare the toxicity of venom towards closely related prey species which were either sympatric or allopatric with the snakes that were the source of the test venoms, because geographic associations between potential prey and venomous snakes have been shown to influence the response of the prey to venom (Heatwole and Poran, 1995; Heatwole and Powell, 1998). In addition, some native mammals, such as Neotoma woodrats, show remarkable resistance to venoms of rattlesnakes (Perez et al., 1978), suggesting coevolutionary adjustments with these potential predators. Finally, to limit any confounding effects of inter-individual variation, we restricted our sources of venom to a single individual from each Sistrurus taxon.

  • Screening for fibrinolytic activity in eight Viperid venoms

    1999, Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology
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