Elsevier

Virology

Volume 32, Issue 1, May 1967, Pages 52-59
Virology

Studies on the relationship between adeno-associated virus type I (AAV-1) and adenoviruses: I. Replication of AAV-1 in certain cell cultures and its effect on helper adenovirus

https://doi.org/10.1016/0042-6822(67)90251-6Get rights and content

Abstract

AAV type 1 has been shown to replicate in several species of cell cultures with the aid of certain helper adenoviruses from man, monkey, mouse, and dog. However, during the course of AAV replication the yield of the helper adenovirus was decreased. The reduction in yield of adenovirus was directly related to the quantity of AAV present and inversely- to the dose of the adenovirus challenge. The decrease in adenovirus yield was shown to be due to a reduction in the number of cells yielding virus.

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    This work was supported by U.S. Public Health Service research grant No. CA-04574 from the National Cancer Institute.

    2

    Present address: Institute for Biomedical Research, Education and Research Foundation, American Medical Association, 535 North Dearborn Street, Chicago, Illinois 60610.

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