Elsevier

Virology

Volume 53, Issue 1, May 1973, Pages 142-151
Virology

Endogenous type C virus from a cat cell clone with properties distinct from previously described feline type C virus

https://doi.org/10.1016/0042-6822(73)90473-XGet rights and content

Abstract

A type C virus has been isolated from a continuous line of feline kidney fibroblasts (CCC). The virus particle contains a reverse transcriptase and group-specific protein which cross react immunologically with the analogous proteins of RD-114 but not with the previously described feline leukemia-sarcoma viruses. A cloned line of non-virus-producing CCC cells isolated prior to the “spontaneous” activation of the CCC virus contains a type C virus which is produced after iododeoxy-uridine treatment. The reverse transcriptase and gs protein of the induced virus also share antigenic properties with the same proteins of RD-114 but not the feline leukemia-sarcoma viruses. Induction from a virus-free, single cell clone establishes that CCC virus is an endogenous feline type C virus. Virus-negative CCC cells and feline embryo cells are resistant to exogenous infection by either the induced or the spontaneously appearing CCC virus; however, human and other primate cells readily support their replication. Thus, certain primate, but not feline cells, appear to be permissive hosts for growth of an endogenous type C virus of the cat.

References (29)

  • V. Klement et al.

    Rescue of the genome of focus-forming virus from rat nonproductive lines by 5-bromodeoxyuridine

    Nature (London)

    (1971)
  • V. Klement et al.

    Rat C-type virus induced in rat sarcoma cells by 5′-bromodeoxyuridine

    Nature New Biol. (London)

    (1972)
  • L.M. Lee et al.

    Use of an established cat cell line for investigation and quantitation of feline oncornaviruses

    J. Nat. Cancer Inst.

    (1972)
  • C. Long et al.

    Specificity of antibody to the RD-114 polymerase

    Nature (London)

    (1973)
  • Cited by (77)

    • Primate type-C oncoviruses

      1980, Biochimica et Biophysica Acta - Reviews on Cancer
    • Envelope antigens of oncoviruses

      1979, Advances in Virus Research
    • Feline leukemia: Recent developments on the causes and immunoprevention of the disease

      1978, Comparative Immunology, Microbiology and Infectious Diseases
    View all citing articles on Scopus
    View full text