Elsevier

Virology

Volume 176, Issue 2, June 1990, Pages 643-647
Virology

Short communication
Complete nucleotide sequence of dengue type 3 virus genome RNA

https://doi.org/10.1016/0042-6822(90)90037-RGet rights and content

Abstract

The complete nucleotide sequence of the genome of the dengue virus type 3 was determined. Sequence analyses of the genomic RNA and cloned cDNA revealed that the genomic RNA contains 10,696 nucleotides and encodes a single open reading frame of 10,170 nucleotides corresponding to 3390 amino acid residues. The N-terminal amino acid sequences of three structural proteins (C, M, and E proteins) and the preM protein were also determined from the purified virion. When the deduced amino acid sequence and N-terminal amino acid sequence determined from purified proteins were compared with those of other flaviviruses, the genome organization was found to be the same as that of other flaviviruses.

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