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Cited by (95)
Spatial Analysis of Single Fiber Cells of the Developing Ocular Lens Reveals Regulated Heterogeneity of Gene Expression
2018, iScienceCitation Excerpt :In the adult lens, 95% of the volume of this tissue is occupied by fiber cells (Bassnett et al., 2011; Costello et al., 2016), which synthesize crystallins to achieve transparency and maintain a specific refractive index (RI) (Iribarren, 2015). A critical feature of this phenotype (transparency), which is set up very early in development (Peetermans et al., 1987) is that it is characterized by a gradient of RI, which follows the gradient of protein concentration, low in the periphery and highest in the center/visual axis (Campbell and Hughes, 1981; Chakraborty et al., 2014; Philipson, 1969; Pierscionek et al., 1987) (Pierscionek and Regini, 2012). A smoother gradient of RI assures pinpoint focus without spherical aberration.
Effect of a contact lens on mouse retinal in vivo imaging: Effective focal length changes and monochromatic aberrations
2018, Experimental Eye ResearchRefractive index measurement of the mouse crystalline lens using optical coherence tomography
2014, Experimental Eye ResearchCitation Excerpt :In the present study, the index of refraction was measured only at the optical axis of the lens, and the crystalline lens was represented as an optical medium of homogenous refractive index (Massof and Chang, 1972). This may not necessarily reflect the true refractive index of the tissue because the crystalline lens in murine eyes follow a gradient of refractive index (Campbell and Hughes, 1981; Phillipson, 1969), producing variations in optical power of the lens throughout its surface, which has been shown to be essential for predicting the optimum refractive state in rodent eyes (Campbell and Hughes, 1981). Therefore, an increase or decrease in the refractive index of the crystalline lens may alternatively represent changes in the refractive index gradient profile of the lens.
Effect of plasma generation on the performance of the crystalline lens
2013, Optics CommunicationsThe gradient index lens of the eye: An opto-biological synchrony
2012, Progress in Retinal and Eye ResearchCitation Excerpt :The cross-sectional profile of an optical fibre preform, with concentric core and cladding layers, is similar to the approximately concentric layered structure of the eye lens. Chu's method was extended by Barrell and Pask (1978) to non-circular optical fibre preforms and first applied to the eye lens of the rat by Campbell and Hughes (1981) and subsequently by Campbell (1984). These ray tracing methods were also used to measure the GRIN profiles in goldfish C. auratus auratus (Axelrod et al., 1988); bovine B. primigenius (Pierscionek, 1989), porcine S. domestica (Pierscionek et al., 2005) and human lenses (Pierscionek and Chan, 1989).