PaperChanges in coagulation and fibrinolysis occurring in dogs during hypothermia
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Heated Humidified Breathing Circuit Rewarming in Hypothermic Patients Post-Cardiopulmonary Bypass—Pilot Study
2022, Journal of Cardiothoracic and Vascular AnesthesiaExtracorporeal cardiopulmonary support may be an efficient rescue of patients after massive pulmonary embolism. An experimental porcine study
2012, Thrombosis ResearchCitation Excerpt :According to previous studies tissue plasminogen activator (t-PA) is less effective in vivo at a subnormal temperature [8]. On the other hand an increased autogenic fibrinolytic activity in hypothermic dogs probably caused by an increased secretion of t-PA has been shown long time before CPS was an option [9]. Therapeutic induced mild hypothermia with a core temperature of 32-34 °C for 24 hours after cardiac arrest in comatose survivors has improved neurologic outcome [10,11].
Acquired bleeding disorders
2011, Blood and Bone Marrow Pathology: Expert ConsultImpact of graded hypothermia on coagulation and fibrinolysis
2011, Journal of Surgical ResearchCitation Excerpt :Our finding that AT-III activity was significantly reduced at moderate hypothermia is in agreement with a relatively recent in vitro study, which showed that the rate of inhibition of thrombin by AT-III was reduced by 5% at 33°C and by 64% at 23°C compared with normothermia (37°C) [16]. On the contrary, Yoshihara et al. found that in dogs, AT-III activity was not affected by deep hypothermia 20°C, while Boldt et al. found that the thrombin/antithrombin III complex was increased in patients undergoing cardiopulmonary bypass at 27°C, indicating a tendency for bleeding diathesis [7, 20]. It is possible that the use of different animals or the different settings of the studies may explain the different findings of the above studies.
Acquired bleeding disorders
2011, Blood and Bone Marrow PathologyHigh Transoxygenator Pressure Gradient in a Patient With Polycythemia Vera
2010, Journal of Cardiothoracic and Vascular Anesthesia