Effect of progesterone upon adenylate cyclase activity and cAMP levels on brain areas
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Cited by (36)
Membrane-initiated actions of sex steroids and reproductive behavior: A historical account
2021, Molecular and Cellular EndocrinologyCitation Excerpt :A few years later a brain site for such a rapid action was identified by Ross and collaborators who found that implantation of progesterone in the mesencephalic reticular formation increased lordosis within 15 min in ovariectomized female rats that had been primed with estrogens for 3 days (Ross et al., 1971). This rapid action of progesterone was very puzzling at the time and generated multiple speculations about a possible action of progesterone and its metabolites mediated by interaction with their anesthetic properties or with neurotransmitters activity (Meyerson, 1972; Collado et al., 1985) (see (Gonzalez-Flores et al., 2006) for a more recent overview). Early on, Volwes and Harwood also reported that a single injection of an estrogen or of testosterone transiently increases the defensive behavior of ring doves toward a predator with latencies ranging between 30 min and 2 h (Volwes and Harwood, 1966).
Progesterone alters the activation and typing of the microglia in the optic nerve crush model
2021, Experimental Eye ResearchCitation Excerpt :On the other hand, others indicate that anti-inflammatory phenotype (M2) plays a protective role by secreting anti-inflammatory cytokines/growth factors, such as IL-13, IL-10, and so on (Miron VE et al., 2013). Progesterone has been proved to be effective on some signaling pathways, including the cAMP/PKA (Collado ML et al., 1985), the MARK (Nilsen J and Brinton RD, 2002) and the PI-3K/Akt pathway (Singh, 2001). Moreover, the protective effect on the nervous system remains from spinal cord injury and cerebral stroke models (Allen RS et al., 2016).
Two thalidomide analogs induce persistent estrous behavior and inhibit uterus contractility in rats: The central role of cAMP
2020, Neuroscience LettersCitation Excerpt :A number of studies support the proposal that estrous behavior facilitated by P is likewise mediated by the AC/PKA/cAMP pathway. in vitro experiments performed by Collado et al. [9] showed that P increased cAMP concentrations in E2-primed tissues from the ventromedial hypothalamus and preoptic area (involved in the expression of lordosis); the cAMP response followed a time course that was similar to that of P on sexual behavior in vivo. However, this model has been questioned because it is unclear whether PKA phosphorylates the PR.
Progesterone-induced neuroprotection: Factors that may predict therapeutic efficacy
2013, Brain ResearchCitation Excerpt :Further, we found that neurotrophin signaling was necessary for progesterone induced protection (Jodhka et al., 2009). With respect to “non-genomic” or cell signaling mechanisms underlying progesterone's protective effects, progesterone has been shown to elicit rapid effects on specific signaling pathways including the cAMP/PKA (Collado et al., 1985), MAPK (ERK1/2) (Migliaccio et al., 1998; Nilsen and Brinton, 2002a; Singh, 2001) and the PI-3K/Akt pathway (Singh, 2001), all of which have been implicated in mediating neuroprotective effects. Progesterone-induced neuroprotection has not only been correlated with activation of the MAPK and Akt signaling pathways (Nilsen and Brinton, 2002a, 2003) but has also been shown to depend on the activation of these pathways (Kaur et al., 2007).
Progesterone and neuroprotection
2013, Hormones and BehaviorCitation Excerpt :In addition to the regulation of gene transcription, progesterone can also elicit its effects via non-genomic mechanisms such as through the activation of signal transduction pathways. Among those second messenger/signal transduction systems now known to be activated by progesterone include cAMP/PKA (Collado et al., 1985), MAPK (ERK1/2) (Migliaccio et al., 1998; Singh, 2001) and the PI-3K/Akt pathway (Singh, 2001). Activation of such signaling pathways has, in fact, been implicated in its neuroprotective effects (see below).
A role for Src kinase in progestin facilitation of estrous behavior in estradiol-primed female rats
2010, Hormones and Behavior