An evaluation of the mechanism of scopolamine-induced impairment in two passive avoidance protocols
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2021, Neuroscience and Biobehavioral ReviewsCitation Excerpt :The shortest protocol for an inhibitory avoidance test therefore comprises of two trials: a single acquisition trial, followed by a single retention trial generally run 24 h later (Bartus et al., 1980; Bohdanecký and Jarvik, 1967; Jarvik and Kopp, 1967). The downside of this protocol is the large inter-individual variability of responses, which implies that a fairly large sample size is usually required to obtain statistically meaningful information (Elrod and Buccafusco, 1988; Lamberty and Gower, 1990). Other commonly used protocols are the multiple-trial acquisition protocols, in which acquisition trials are run either successively or with a 24-h inter-trial interval, and in which a single retention trial is run on the last day of testing (Graham and Buccafusco, 2001; Ray and Nagy, 1978).
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2017, PeptidesCitation Excerpt :On the 71st h of PTZ or saline (control group) injection, the rats were again placed in the illuminated compartment to evaluate the passive avoidance response. Based on the previous reports [22], the rats that have avoided entering the dark chamber with a latency over 300 s were considered to have normal learning and memory performance, while a shorter latency to enter the dark chamber was regarded as memory dysfunction. Brain tissues were homogenized with ice-cold trichloroacetic acid (10% per 1 g tissue) with Ultra Turrax tissue homogenizer.