Serotonergic innervation of the rat caudate following a neonatal 6-hydroxydopamine lesion: An anatomical, biochemical and pharmacological study☆
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Cited by (104)
Neurobehavioral changes arising from early life dopamine signaling perturbations
2020, Neurochemistry InternationalEffects of prolonged neuronal nitric oxide synthase inhibition on the development and expression of l-DOPA-induced dyskinesia in 6-OHDA-lesioned rats
2015, NeuropharmacologyCitation Excerpt :The reduction of 5-HT levels might be functional rather than structural and may represent a secondary effect of severe dopaminergic depletion. However, the data regarding striatal 5-HT levels after dopaminergic injury are controversial, and striatal 5-HT levels are reported to remain unchanged (Carta et al., 2007; Dupre et al., 2007; Gil et al., 2011) or increase (Guerra et al., 1997; Rozas et al., 1998; Snyder et al., 1986; Stachowiak et al., 1984; Towle et al., 1989; Zhou et al., 1991). Possible explanations for the discrepancy could be the extent of the lesion, the survival time after lesioning and the site of microinjection.
The serotonergic system in Parkinson's disease
2011, Progress in NeurobiologyStriatal 6-OHDA lesion in mice: Investigating early neurochemical changes underlying Parkinson's disease
2010, Behavioural Brain ResearchCitation Excerpt :Although the serotonergic and dopaminergic systems are known to critically interact in the pathophysiology of the basal ganglia [22,53], it is not surprising that 5-HT levels are preserved following a moderate DA depletion. Indeed, significant changes in 5-HT levels (namely, compensatory increase or decrease after neonatal and adult 6-OHDA lesion, respectively), were only found after a massive (>90%) DA denervation [31,59,62]. The moderate DA depletion found here, however, was enough to trigger an increase in 5-HT turnover, as revealed by the significant increase in the 5-HIAA/5-HT ratio.
Diminished serotonergic innervation of adult medial prefrontal cortex after 6-OHDA lesions in the newborn rat
2005, Developmental Brain ResearchThe neonate-6-hydroxydopamine-lesioned rat: A model for clinical neuroscience and neurobiological principles
2005, Brain Research ReviewsCitation Excerpt :Nonetheless, because of ambiguity concerning the means by which specific serotonin receptor subtypes contribute to D1-dopamine receptor sensitization, this area of neonate-lesioned neurobiology should receive additional scrutiny. Accompanying the robust striatal serotonergic hyperinnervation in the neonate-lesioned rats [12,22,107,147,148,157] is an increase in striatal 5-HT receptors, with the greatest elevation observed in 5-HT2 receptor subtypes [131]. In support of altered serotonergic mechanisms in neonate-lesioned rats, m-CPP (meta-chlorophenylpiperazine), a compound presumed to act on 5-HT2C receptors, reportedly enhances chewing, oral activity, head-nodding, and self-biting, after this lesion [3,72,93,95].
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Supported by USPHS Grants HD-03110, MH-36294, NS-21345 and HD-23042.