MK-801 and AP5 impair acquisition, but not retention, of the Morris milk maze
References (13)
- et al.
APV, an N-methyl-deuterium-aspartate receptor antagonist, blocks the hippocampal theta rhythm in behaving rats
Brain Res.
(1988) - et al.
The interaction between MK-801 and receptors for N-methyl-D-aspartate: Functional consequences
Neuropharmacology
(1987) - et al.
Excitatory amino acids in synaptic transmission in the Schaffer collateral commissural pathway of the rat hippocampus
J. Physiol.
(1983) - et al.
Excitatory amino acid neurotransmission: NMDA receptors and Hebb-type synaptic plasticity
Annu. Rev. Neurosci.
(1988) - et al.
Anticonvulsant doses of MK-801 fail to block long-term potentiation in vivo or impair spatial memory in the rat
Neurosci. Lett.
(1987) The organization of behaviour
(1949)
Cited by (170)
Acute effects of ketamine and esketamine on cognition in healthy subjects: A meta-analysis
2022, Progress in Neuro-Psychopharmacology and Biological PsychiatryNMDA receptor dependence of reversal learning and the flexible use of cognitively demanding search strategies in mice
2019, Progress in Neuro-Psychopharmacology and Biological PsychiatryCitation Excerpt :Furthermore, analysis of swim strategies showed that MK-801 mice did not use cognitively demanding spatial search strategies as efficiently as control animals. It should be noted that some other studies did report effects of MK-801 on spatial learning (Filliat and Blanchet, 1995; Tao et al., 2016; Heale and Harley, 1990; McLamb et al., 1990), but Åhlander and colleagues pointed out that these effects were hard to dissociate from non-mnemonic behavioural effects (e.g., increase in locomotor activity; Ahlander et al., 1999). Analysis of motor behaviour in the current MWM test revealed no difference in swim speed and covered distance.
MK-801 and memantine act differently on short-term memory tested with different time-intervals in the Morris water maze test
2016, Behavioural Brain ResearchCitation Excerpt :Neurotoxicity induced by a single administration of a high dose of MK-801 or memantine had no effect on working memory in the radial maze tested with an eight-day delay [53]. Heale and Harkley [54] showed that 0.07 mg/kg of MK-801 impaired the acquisition of performance during two blocks of six trials in the Morris water maze; however, NMDA blocking had no effect on retention. Their results are consistent with the hypothesis that NMDARs are critical for the initiation of synaptic modification, which are necessary for spatial learning, but are not necessary during the retrieval of spatial information [54].
Rhythmic theta and delta activity of cortical and hippocampal neuronal networks in genetically or pharmacologically induced N-methyl-d-aspartate receptor hypofunction under urethane anesthesia
2013, NeuroscienceCitation Excerpt :In healthy humans, NMDAR antagonists elicit schizophrenia-like symptoms and cognitive deficits (Krystal et al., 1994) as well as reproduce certain neurophysiological abnormalities associated with schizophrenia (Javitt et al., 2008). These behavioral and physiological effects of NMDAR blockade have led to the frequent use of these drugs in pre-clinical drug discovery models (Freed et al., 1980; Mansbach and Geyer, 1989; Heale and Harley, 1990; Miller et al., 1992; Homayoun et al., 2005; Kiss et al., 2011a). Our recent experiments have shown that systemic administration of NMDAR antagonists profoundly changes delta band activity in the mPFC in rats, shifting peak frequency and power of oscillations to a low, 1-Hz frequency range (Kiss et al., 2011a).
Memory in aged mice is rescued by enhanced expression of the GluN2B subunit of the NMDA receptor
2013, Behavioural Brain Research