Cell
A possible mammary stem cell line
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Cited by (188)
From shape-shifting embryonic cells to oncology: The fascinating history of epithelial mesenchymal transition
2023, Seminars in Cancer BiologyTumor heterogeneity
2017, Patient Derived Tumor Xenograft Models: Promise, Potential and PracticeHormonal Control of Breast Development
2015, Endocrinology: Adult and PediatricEvolution of the cancer stem cell model
2014, Cell Stem CellCitation Excerpt :Studies to answer these questions require functional assays. Although the idea that cancer retains features of embryological development has a long history (Cohnheim, 1875), the modern idea that developmental programs underlying normal tissue organization may still function to some extent in cancer began with seminal studies of teratocarcinoma (Pierce et al., 1960), small cell lung carcinoma (Baylin et al., 1978), and mammary carcinoma (Bennett et al., 1978; Hager et al., 1981). They suggested that many tumor cells were differentiated and that these “differentiated” cells were generated by tumor “stem” cells, similar to normal tissue stem cells producing normally differentiated tissues.
Statistical association of basal cell keratins with metastasis-inducing proteins in a prognostically unfavorable group of sporadic breast cancers
2011, American Journal of PathologyCitation Excerpt :In addition to the complex of cytokeratins that include CK5/6 and CK14 being found in basally situated smooth muscle actin/myosin-containing myoepithelial cells,6 they are also detected in occasional suprabasal epithelial cells, particularly in growing terminal ductal structures.31,51–53 The observations of intermediate cell forms between the more peripheral cells in these structures and the subtending epithelial and myoepithelial cells52,54,55 are in line with findings in cultured human breast epithelial cells56,57 that a subclass of epithelial-like cells containing basal cell cytokeratins54,55,58 progressively differentiates into myoepithelial or into luminal epithelial cells, as reported originally in rodent systems.59–61 Thus, the basal-like breast carcinomas may contain the vestiges of a normal breast stem cell that has lost its capability to differentiate completely into end-stage myoepithelial cells,58,62,63 but still expresses basal cell cytokeratins,64 as well as CK19,65,66 vimentin,67 CD44,68 ALDH1,69 and/or CD133.70
Interaction in vivo and in vitro of the metastasis-inducing S100 protein, S100A4 (p9Ka) with S100A1
2000, Journal of Biological ChemistryCitation Excerpt :The heterodimerization of S100A1 and S100A4 reported here might be expected to have biological significance if these S100 proteins occur in the same cells. These proteins have been shown to coexist in the same cultured human breast cancer cells and in rat mammary cells, Rama 29 (not shown) (30), and coexpression of S100A1 and S100A4 has been reported previously in primary cultures and cell lines of human vascular smooth muscle cells (14). In the present experiments, S100A1 and S100A4 are both located in the perinuclear region and on the stress fibers of the cytoskeleton.