Cell
ArticleTransgenic mice harboring SV40 t-antigen genes develop characteristic brain tumors
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2021, Advanced Drug Delivery ReviewsCitation Excerpt :Genetic and biotechnology advances for nearly four decades enabled the development of precise GEMM, carrying specific aberrations present in human malignancies [274,275]. GEMM can be generated by different technologies, namely by using i) tissue-specific promoters to drive the expression of an oncogene (e.g., simian virus 40 (SV40) large T antigen [276–278]) or oncogenes related to tumor development (e.g., Kras [279–281], MYC [282,283], epidermal growth factor receptor (EGFR) [284] and BRAF V600E [285,286])), or ii) recombinase enzymes, such as Tet-on/off [281,287,288], tamoxifen-inducible Cre recombinase [289,290] and clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 technology that eliminate tumor suppressor genes (e.g. TP53 [291–293], adenomatous polyposis coli (APC) [292,294], and phosphatase and tensin homolog (PTEN)) [291,292,294]. Contrarily to the previous tumor models, tumors in GEMM develop spontaneously in a tissue-specific manner, which mimic more closely the natural tumor development and progression, and therefore also harbor a TME similar to the human malignancies.
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