Cell
ArticlePlakoglobin: A protein common to different kinds of intercellular adhering junctions
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2018, Molecular and Cellular EndocrinologyCitation Excerpt :Our cellular model reflects that the control of spermatogenesis is induced by FSH in SC in vivo. PLKA is a constitutive protein of desmosomes and adherent junctions at the blood-testis barrier with structural and signalling roles (Cowin et al., 1986). PLKA interacts with junctional proteins such as desmosomal cadherins, classical cadherins and α-catenin.
β-catenin coordinates with Jup and the TCF1/GATA6 axis to regulate human embryonic stem cell fate
2017, Developmental BiologyCitation Excerpt :Notably, depletion of Ctnnb1 has no effect on hESC adhesion, although it is an integral component of adherens junctions (Kemler, 1993). Jup also participates in adherens junctions and has been shown to compensate for the loss of Ctnnb1 (Cowin et al., 1986; Lyashenko et al., 2011; Zhou et al., 2007). For example, in Ctnnb1-deficient mESCs, JUP levels are elevated and could rescue cell adhesion; therefore, knockdown of Jup in Ctnnb1 knockout mESCs disrupts adhesion (Lyashenko et al., 2011).
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Present address: Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA.