Cell
ArticleEpigenetic control of transgene expression and imprinting by genotype-specific modifiers
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Metastable epialleles and their contribution to epigenetic inheritance in mammals
2020, Seminars in Cell and Developmental BiologyCitation Excerpt :For some transgenes, variable expressivity is recapitulated from one generation to the next in a predictable manner [66,67]. Others exhibit memory of parental methylation level, their silenced state stably inherited to subsequent generations after passage through the germline [65,68–70]. This heritable silencing is sometimes irreversible, and at other times reactivated upon transmission through the other parent or by crossing to a different strain.
Mouse models of epigenetic inheritance: Classification, mechanisms, and experimental strategies
2017, Handbook of Epigenetics: The New Molecular and Medical GeneticsSynthetic biology of metabolism: Using natural variation to reverse engineer systems
2014, Current Opinion in Plant BiologyCitation Excerpt :There are several major lines of evidence that the genetic background plays a determinant role in controlling the success of any synthetic or forward engineering approach in an organism. First in almost every species tested, introduction of a specific transgene into different natural varieties led to significantly different results in each genotype [10–12]. This was even when using multiple independent events per background as with mice or Drosophila [10,11].
Towards the Molecular Mechanisms of Transgenerational Epigenetic Inheritance. Insights from Transgenic Mice.
2014, Transgenerational EpigeneticsPancreas-specific Cre driver lines and considerations for their prudent use
2013, Cell MetabolismCitation Excerpt :Silencing of transgene expression can occur within a single generation or more gradually over several generations. Finally, the genetic background may also influence the extent of variegation, perhaps due to chromosomal differences between inbred strains of mice (Allen et al., 1990). Due to the deficiencies of transgenes containing short driver DNA fragments, two other strategies have gained favor for deriving Cre driver lines that exhibit expression patterns that closely match that of the driver gene.