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Variations of cervical vertebrate after expression of a Hox-1.1 transgene in mice
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Transgenic human HOXB1-9 directs anterior-posterior axial skeleton pattern in Hoxb1-9 deficient mice
2022, DifferentiationCitation Excerpt :The originally proposed Hox code stated that the identity of each vertebral segment depended on the combination of different Hox genes expressed in a prevertebral segment (Kessel and Gruss, 1991). Hox transgene overexpression or loss of multiple paralogous Hox genes can dramatically alter the Hox code, resulting in vertebral identity changes (Jegalian and De Robertis, 1992; Kessel et al., 1990; Lufkin et al., 1992; McIntyre et al., 2007; Pollock et al., 1992; Wellik and Capecchi, 2003). One of the consequences of the anterior thoracic vertebral transformations in the HoxB1-9Δ/Δ mice is a shift in forelimb position.
Accessory articulation of the transverse processes in the cervical spine
2022, Radiology Case ReportsCitation Excerpt :Another explanation for this accessory articulation could derive from the pivotal role of homeobox (Hox) genes in the regulation of vertebral development [21–23]. Previous studies have established the function of the Hox genes in the patterning of the axial skeleton through both gain-of-function and loss-of-function experiments [24–27]. Thus, aberrations in the Hox genes’ regulation of segmental differentiation could explain the elongation of the anterior tubercles of the cervical transverse processes.
Bones and Cartilage: Developmental and Evolutionary Skeletal Biology
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