Cell
Volume 70, Issue 6, 18 September 1992, Pages 901-910
ArticleDominant negative MYC blocks transformation by ABL oncogenes
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2021, Biochemical PharmacologyCitation Excerpt :c-Myc is related to BCR-ABL transformation and plays a crucial role in CML progression from the chronic phase to blast crisis. Inhibiting c-Myc induces reduced BCR-ABL activity [53,54] because c-Myc binds to the BCR promoter and directly regulates BCR activity [45]. These reports indicate that IL-8 secretion is associated with BCR-ABL activity.
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