Cell
ArticleProcessed Vg1 protein is an axial mesoderm inducer in xenopus
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2020, Current Topics in Developmental BiologyOrganizing the oocyte: RNA localization meets phase separation
2020, Current Topics in Developmental BiologyCitation Excerpt :Generally, the late pathway is used to localize RNAs, such as vg1 and vegT, which are necessary for germ-layer patterning in the embryo (Birsoy, Kofron, Schaible, Wylie, & Heasman, 2006; Joseph & Melton, 1998; Kofron et al., 1999; White & Heasman, 2008; Zhang et al., 1998). Importantly, spatially inappropriate expression of either vg1 and vegT mRNAs, which encode, respectively, a TGFβ growth factor family member and a T-box transcription factor, cause lethal embryonic phenotypes (Thomsen & Melton, 1993; Wallace & Dumont, 1968; Zhang & King, 1996). In stage I oocytes, while early localizing RNAs are enriched within the Balbiani body, late localizing RNAs are distributed ubiquitously in the cytoplasm, indicating a clear mechanistic distinction between the two pathways.
Signaling events regulating embryonic polarity and formation of the primitive streak in the chick embryo
2020, Current Topics in Developmental Biology
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Present address: Department of Biochemistry and Cell Biology, State University of New York at Stony Brook, Stony Brook, New York 11794-5215.