Topographic organization of sensory projections to the olfactory bulb

doi:10.1016/0092-8674(94)90029-9

Cell

Volume 79, Issue 6, 16 December 1994, Pages 981-991

https://doi.org/10.1016/0092-8674(94)90029-9 Get rights and content

Abstract

The detection of odorant receptor mRNAs within the axon terminals of sensory neurons has permitted us to ask whether neurons expressing a given receptor project their axons to common glomeruli within the olfactory bulb. In situ hybridization with five different receptor probes demonstrates that axons from neurons expressing a given receptor converge on one, or at most, a few glomeruli within the olfactory bulb. Moreover, the position of specific glomeruli is bilaterally symmetric and is constant in different individuals within a species. These data support a model in which exposure to a given odorant may result in the stimulation of a spatially restricted set of glomeruli, such that the individual odorants would be associated with specific topographic patterns of activity within the olfactory bulb.

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^*: Present address: Department of Physiology, University of California, San Francisco, San Francisco, California 94143.

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Cell

Topographic organization of sensory projections to the olfactory bulb

Abstract

Brain Res. Bull.

Brain Res.

Cell

Cell

Mol. Brain Res.

Dev. Biol.

Cell

Brain Res.

Brain Res.

Brain Res.

J. Steroid Biochem. Mol. Biol.

Dev. Brain Res.

Brain Res.

Neuron

Cell

Curr. Opin. Neurobiol.

Cell

Brain Res.

Brain Res. Bull.

Brain Res.

Trends Neurosci.

Cell

Cell

Olfactory glomeruli in the zebrafish form an invariant pattern and are identifiable across animals

J. Neurosci.

Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire

Hum. Mol. Gen.

Multiple systems diverging from the dorsal column nuclei in the cat

Identification of a peptide specific for Aplysia sensory neurons by PCR-based differential screening

Science

The projections of mitral cells from small local regions of the olfactory bulb: an anterograde tracing study using PHA-L (Phaseolus vulgaris Leucoagglutinin)

Eur. J. Neurosci.

Patterned activity, synaptic convergence, and the NMDA receptor in developing visual pathways

Annu. Rev. Neurosci.

Submodality segregation and receptive-field sequences in cuneate, gracile, and external cuneate nuclei of the cat

J. Neurophysiol.

Cloning by functional expression of a member of the glutamate receptor family

Nature