Cell
Volume 81, Issue 4, 19 May 1995, Pages 631-639
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Article
Semaphorin II can function as a selective inhibitor of specific synaptic arborizations

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Abstract

Previous studies showed that grasshopper semaphorin I, a transmembrane semaphorin, functions in vivo to steer a pair of growth cones, prevent defasciculation, and inhibit branching; and that chick collapsin, a secreted semaphorin, can function in vitro to cause growth cone collapse. Semaphorin 11, a secreted semaphorin in Drosophila, is transiently expressed by a single large muscle during motoneuron outgrowth and synapse formation. To test the in vivo function of semaphorin 11, we created transgenic Drosophila that generate ectopic semaphorin 11 expression by muscles that normally do not express it. The results show that semaphorin II can function in vivo as a selective target-derived signal that inhibits the formation of specific synaptic terminal arbors.

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Present address: Department of Neuroscience, Johns Hopkins University Medical School, Baltimore, Maryland 21205.