Elsevier

The Lancet

Volume 338, Issue 8769, 21 September 1991, Pages 725-726
The Lancet

SHORT REPORTS
Prevention of chronic Pseudomonas aeruginosa colonisation in cystic fibrosis by early treatment

https://doi.org/10.1016/0140-6736(91)91446-2Get rights and content

Abstract

To assess whether chronic pulmonary colonisation with Pseudomonas aeruginosa in cystic fibrosis is preventable, 26 patients who had never received anti-pseudomonas chemotherapy were randomly allocated to groups receiving either no anti-pseudomonas chemotherapy or oral ciprofloxacin and aerosol inhalations of colistin twice daily for 3 weeks, whenever Ps aeruginosa was isolated from routine sputum cultures. During the 27 months of the trial, infection with Ps aeruginosa became chronic in significantly fewer treated than untreated subjects (2 [14%] vs 7 [58%]; p<0·05) and there were significantly fewer Ps aeruginosa isolates in routine sputum cultures in the treated group (49/214 [23%] vs 64/158 [41%]; p=0·0006). Thus, chronic colonisation with Ps aeruginosa can be prevented in cystic fibrosis by early institution of anti-pseudomonas chemotherapy.

References (10)

There are more references available in the full text version of this article.

Cited by (447)

  • 51 - Pulmonary Disease in Cystic Fibrosis

    2019, Kendig's Disorders of the Respiratory Tract in Children
View all citing articles on Scopus
View full text