Elsevier

The Lancet

Volume 338, Issue 8780, 7 December 1991, Pages 1422-1423
The Lancet

SHORT REPORTS
βA4 amyloid protein deposition in brain after head trauma

https://doi.org/10.1016/0140-6736(91)92724-GGet rights and content

Abstract

Previous reports have suggested that both repetitive head trauma and a single injury can be associated with the presence of diffuse βA4 amyloid protein plaques in long-term survivors. We have studied sixteen patients (aged 10-63 years) who sustained head injury and survived for only 6-18 days. Immunostaining with an antibody to βA4 amyloid showed extensive deposits of the protein in the cortex in six of the sixteen patients (38%). Thus, severe head injury can trigger βA4 deposition in the brain within days.

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