PaperConversion of 3-cyanopyridine to nicotinic acid by Nocardia rhodochrous LL100-21
References (23)
- et al.
- et al.
Adv. Biochem. Eng.
(1980) - et al.
Agric. Biol. Chem.
(1982) - et al.
Agric. Biol. Chem.
(1982) - et al.
Appl. Environ. Microbiol.
(1976) - et al.
J. Gen. Microbiol.
(1983) - et al.
J. Gen. Microbiol.
(1986) - et al.
J. Gen. Microbiol.
(1984) - et al.
Entropie
(1982) - Yamaguchi, T., Wantabe, I. and Satoh, Y. U.S. Patent 4,440,858, April 3,...
Biochem. J.
Cited by (29)
Bench scale production of nicotinic acid using a versatile amide-hydrolysing Geobacillus subterraneus RL-2a isolated from thermal spring of Manikaran, India
2014, Journal of Molecular Catalysis B: EnzymaticCitation Excerpt :Nicotinic acid is manufactured through several chemical methods which require high temperature and pressure [8]. Alternative to chemical processes is the use of microbial enzymes (nitrilase or nitrile hydratase and amidase) that hydrolyse 3-cyanopyridine to nicotinic acid [9,10]. Nicotinic acid production from thermostable enzyme (nitrilase) was previously reported with Bacillus pallidus Dac21 [11].
Biotransformation of 3-cyanopyridine to nicotinic acid by free and immobilized cells of recombinant Escherichia coli
2014, Process BiochemistryCitation Excerpt :Total bioconversion (100%) at 200 mM substrate level was reported using whole cells of Bacillus pallidus whereas substrate inhibition was found at 300 mM 3-cyanopyridine [4]. Bioconversion using whole cells of Microbacterium imperiale in continuous stirred tank membrane reactor (CSMR) was also reported with a yield of 200 mM nicotinic acid [5,6,7,12] in 24 h. Using whole cells of Nocardia rhodochrous, nicotinic acid yield of 0.5 M was reported in literature [13]. A nicotinic acid yield of 40 mM was also mentioned in literature using whole cells of Nocardia globerula [8].
Reactive extraction of picolinic and nicotinic acid by natural non-toxic solvent
2013, Separation and Purification TechnologyCitation Excerpt :Biological synthesis follows enzymatic conversion of 3-cyanopyridine to nicotinic acid by using resting R. rhodochrous JI cells containing high benzonitrilase activity [5]. Another route follows enzymatic conversion of 3-cyanopyridine to nicotinic acid by Nocardia rhodochrous LL100-21 [6]. Amidase-catalyzed production of nicotinic acid in batch and continuous stirred membrane reactors was studied by Maria et al. [7].
Amidase-catalyzed production of nicotinic acid in batch and continuous stirred membrane reactors
2008, Enzyme and Microbial TechnologyNocardia globerula NHB-2: Bench scale production of nicotinic acid
2006, Process BiochemistryThermostable nitrilase catalysed production of nicotinic acid from 3- cyanopyridine
1999, Enzyme and Microbial Technology