The spontaneously hypertensive rat (SHR) as an animal model of childhood hyperactivity (ADHD): changed reactivity to reinforcers and to psychomotor stimulants
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Cited by (206)
Conditioned approach behavior of SHR and SD rats during Pavlovian conditioning
2023, Behavioural Brain ResearchThe translational genetics of ADHD and related phenotypes in model organisms
2023, Neuroscience and Biobehavioral ReviewsReview of rodent models of attention deficit hyperactivity disorder
2022, Neuroscience and Biobehavioral ReviewsEvolutionary conservations, changes of circadian rhythms and their effect on circadian disturbances and therapeutic approaches
2021, Neuroscience and Biobehavioral ReviewsSpontaneously hypertensive (SHR) rats choose more impulsively than Wistar-Kyoto (WKY) rats on a delay discounting task
2019, Behavioural Brain ResearchCitation Excerpt :Investigating the impulsive choices of the SHR is important because the SHR strain of rats is used as an animal model of Attention Deficit Hyperactivity Disorder (ADHD), capturing the notion that ADHD is a developmental disorder [29], and this idea is consistent with theoretical approaches predicting ADHD [30]. Derived from the WKY and originally selected for its hypertensive phenotype (high systolic blood pressure) [31], the SHR shows behavioral symptoms of ADHD such as poor sustained attention [32], learning insufficiencies [33], resistance to extinction [34], memory deficits [35], hyperactivity [36,37], hypersensitivity to delayed consequences [38], and impulsivity [8,39]. The WKY, then, may serve as a useful control to the SHR [44,29,30], and these two animal models can be used to examine aspects of impulsivity characterizing ADHD [45–48].
- 1
Current address: The National Cerebral Palsy Hospital, Oslo, Norway.
- 2
Current address: The National Hospital for Epilepsy, Sandvika, Norway.
- 3
These studies were supported by the Norwegian Research Council for Science and the Humanities Grant 326.91/039 (T.S.) and by NSF Grant BNS-9020357 (M.A.M.).