Performance of nonpsychotic relatives of schizophrenic patients on cognitive tests

doi:10.1016/0165-1781(94)90091-4

Psychiatry Research

Volume 53, Issue 1, July 1994, Pages 1-12

https://doi.org/10.1016/0165-1781(94)90091-4 Get rights and content

Abstract

We tested 54 nonpsychotic first degree relatives of 23 schizophrenic probands and 18 control subjects matched for age and education on several neuropsychological tests. The tests were selected to assess overall intellectual ability or because previous work indicated that they are particularly sensitive measures of cognitive dysfunction in schizophrenic patients. The relatives of schizophrenic patients performed significantly worse than the control subjects on tests of verbal fluency and on Trailmaking, part B. Each of these tests contributed unique variance to the discrimination between groups. The groups did not differ significantly on the number of perserverative errors on the Wisconsin Card Sorting Test, Wechsler Adult Intelligence Scale-Revised block design or vocabulary, or Trailmaking, part A. Eight relatives who met DSM-III-R criteria for schizotypal personality disorder were more impaired than the remaining 46 relatives on letter fluency, but otherwise their performance was similar to that of nonschizotypal relatives. These data suggest that close relatives of schizophrenic patients may have subtle neuropsychological impairments that are not necessarily associated with clinical symptoms of schizophrenia spectrum disorders.

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Performance of nonpsychotic relatives of schizophrenic patients on cognitive tests

Abstract

Neuropsychologia

Biological Psychiatry

Cortex

Neuropsychologia

Clinical Psychology Review

Selective retrieval and free emission of category exemplars in schizophrenia

British Journal of Psychology

DSM-III-R: Diagnostic and Statistical Manual of Mental Disorders

Wisconsin Card Sorting performance as a measure of frontal lobe damage

Journal of Clinical and Experimental Neuropsychology

The Comprehensive Assessment of Symptoms and History (CASH): An instrument for assessing psychopathology and diagnosis

Archives of General Psychiatry

A family study of schizophrenic and normal control probands: Implications for the spectrum concept of schizophrenia

American Journal of Psychiatry

Auditory P300 and eye tracking dysfunction in schizophrenic pedigrees

Archives of General Psychiatry

Normative data on selected neuropsychological measures from a nonclinical sample

Journal of Clinical Psychology

Normative data on the Boston Diagnostic Aphasia Examination, Parietal Lobe Battery, and the Boston Naming Test

Journal of Clinical Neuropsychology

The generalized pattern of neuropsychological deficits in outpatients with chronic schizophrenia with heterogeneous Wisconsin Card Sorting Test result

Archives of General Psychiatry

Global attentional deviance as a marker of risk for schizophrenia: Specificity and predictive validity

Journal of Abnormal Psychology

The influence of age on Trail Making Test performance

Journal of Clinical Psychology

A diagnostic review: The Schedule for Affective Disorders and Schizophrenia

Archives of General Psychiatry

The performance of young schizophrenics on the Wisconsin Card Sorting Test

Journal of Consulting and Clinical Psychology

Normative data for the Halstead-Reitan neuropsychological tests

Journal of Clinical Neuropsychology

Contrasts between patients with affective disorders and patients with schizophrenia on a neuropsychological test battery

American Journal of Psychiatry

Learning and memory in monozygotic twins discordant for schizophrenia

Psychological Medicine

Probing prefrontal function in schizophrenia with neuropsychological paradigms

Schizophrenia Bulletin