Neuropeptide abnormalities in anorexia nervosa☆
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Cited by (89)
Antagonism for NPY signaling reverses cognitive behavior defects induced by activity-based anorexia in mice
2021, PsychoneuroendocrinologyCitation Excerpt :Previous studies have shown that mRNA levels of AgRP and NPY in the hypothalamus of ABA rats are higher (de Rijke et al., 2005). Elevated levels of AgRP in plasma and NPY in cerebrospinal fluid have been observed in AN patients (Kaye, 1996; Moriya et al., 2006). Higher levels of AgRP and NPY were observed in the present study.
Anorexia Nervosa, Bulimia Nervosa, and Other Eating Disorders
2015, Endocrinology: Adult and PediatricFood choice in disorders of eating behavior: Correlations with the psychopathological aspects of the diseases
2014, Comprehensive PsychiatryCitation Excerpt :Specifically, brain dopamine (DA) exerts a suppressive effect on protein and fat intake and stimulates carbohydrate consumption [30–32]; norepinephrine (NE) stimulates protein intake by acting on presynaptic alpha-2 receptors and carbohydrate intake [33,34]; serotonin (5-HT) inhibits protein, carbohydrate and fat consumption [34]; neuropeptides Y (NPY) and opioids increase carbohydrate intake, while cholecystokinin (CCK) decreases fat consumption [34–36]. Conversely, carbohydrates increase the secretion in the brain of DA, NE, 5-HT, NPY and opioids and decrease gastric secretion of ghrelin [32,37–39]; proteins decrease brain 5-HT secretion and gastric ghrelin release [39], and fat increases the production of 5-HT, catecholamines, opioids, and CCK and decreases the production of NPY and leptin [39–44], while a mixture of carbohydrates and fats stimulates dynorphin secretion [35]. Altered secretion of 5-HT, NE and DA in AN and BN has been repeatedly reported, with decreases of the three amines in the acute phase of the diseases and improvement in 5-HT and NE with lower than normal DA secretion still present one year after recovery from the disorder [45–49].
The contributions of oxytocin and vasopressin pathway genes to human behavior
2012, Hormones and BehaviorAnorexia Nervosa, Bulimia Nervosa, and Other Eating Disorders
2010, Endocrinology: Adult and Pediatric, Sixth Edition
- ☆
Proceedings of the meeting “Anorexia nervosa: basic mechanisms, clinical approaches, and treatment”. Geneva, Switzerland, September 27–29, 1993.
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